With the CF Research News, we aim to bridge the gap between people with CF and the researchers investigating CF and how best to treat those with the condition.
We want to provide access to patients, parents, relatives, friends and caregivers of patients with CF to all scientific work mainly published in the Journal of Cystic Fibrosis (JCF).

All PDF files published hereunder are lay version summaries of work published in the JCF.

April 2019

Title: An open-label extension study of ivacaftor in children with CF and a CFTR gating mutation initiating treatment at age 2-5 years (KLIMB).
Authors
Rosenfeld M, Cunningham S, Harris WT, Lapey A, Regelmann WE, Sawicki GS, Southern KW, Chilvers M, Higgins M, Tian S, Cooke J, Davies JC; KLIMB study group.
References
J Cyst Fibros. 2019 Apr 30. pii: S1569-1993(19)30061-X. doi: 10.1016/j.jcf.2019.03.009.
Keywords
CFTR potentiator, Ivacaftor, KLIMB, Pediatrics, Safety
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Scientific Abstract

April 2019

Title: Early glucose abnormalities are associated with pulmonary inflammation in young children with cystic fibrosis
Authors
Prentice BJ, Ooi CY, Strachan RE, Hameed S, Ebrahimkhani S, Waters SA, Verge CF, Widger J
References
J Cyst Fibros. 2019 Apr 26. pii: S1569-1993(18)30897-X. doi: 10.1016/j.jcf.2019.03.010. 
Keywords
CGM, continuous glucose monitoring, Cystic fibrosis-related diabetes, Inflammation
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Scientific Abstract
Title: Early glucose abnormalities are associated with pulmonary inflammation in young children with cystic fibrosis
Authors
Prentice BJ, Ooi CY, Strachan RE, Hameed S, Ebrahimkhani S, Waters SA, Verge CF, Widger J
References
J Cyst Fibros. 2019 Apr 26. pii: S1569-1993(18)30897-X. doi: 10.1016/j.jcf.2019.03.010. 
Keywords
CGM, continuous glucose monitoring, Cystic fibrosis-related diabetes, Inflammation
Scientific Abstract
Title: Early glucose abnormalities are associated with pulmonary inflammation in young children with cystic fibrosis
Authors
Prentice BJ, Ooi CY, Strachan RE, Hameed S, Ebrahimkhani S, Waters SA, Verge CF, Widger J
References
J Cyst Fibros. 2019 Apr 26. pii: S1569-1993(18)30897-X. doi: 10.1016/j.jcf.2019.03.010. 
Keywords
CGM, continuous glucose monitoring, Cystic fibrosis-related diabetes, Inflammation
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Scientific Abstract
Title: Mucoid Pseudomonas aeruginosa and regional inflammation in the cystic fibrosis lung
Authors
Malhotra S, Hayes D Jr, Wozniak DJ
References
J Cyst Fibros. 2019 Apr 26. pii: S1569-1993(19)30069-4. doi: 10.1016/j.jcf.2019.04.009.
Keywords
Airway, Cytokines, Inflammation, Lung; Mucoid, Pseudomonas aeruginosa
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Scientific Abstract
Title: Mucoid Pseudomonas aeruginosa and regional inflammation in the cystic fibrosis lung
Authors
Malhotra S, Hayes D Jr, Wozniak DJ
References
J Cyst Fibros. 2019 Apr 26. pii: S1569-1993(19)30069-4. doi: 10.1016/j.jcf.2019.04.009.
Keywords
Airway, Cytokines, Inflammation, Lung; Mucoid, Pseudomonas aeruginosa
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Scientific Abstract

April 2019

Title: Oxidative Stress and Abnormal Bioactive Lipids in Early Cystic Fibrosis Lung Disease.
Authors
Bob J Scholte, Hamed Horati, Mieke Veltman, Rob J Vreeken, Luke W Garratt, Harm A.W.M Tiddens, Hettie M. Janssens, Stephen M Stick, on behalf of the Australian Respiratory Early Surveillance Team for Cystic Fibrosis (AREST CF)
References
J Cyst Fibros. 2019 Apr 25. pii: S1569-1993(19)30071-2. doi: 10.1016/j.jcf.2019.04.011. 
Keywords
Bronchoalveolar lavage, Isoprostanes, Lysolipids, Mass spectrometry (5), Oxylipins
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Scientific Abstract

April 2019

Title: Assessment of endothelial function is reproducible in patients with cystic fibrosis.
Authors
Derella CC, Lee N, Crandall R, Blackburn M, Looney J, Mangieri A, Rodriguez-Miguelez P, Tucker MA, Harris RA
References
J Cyst Fibros. 2019 Apr 4. pii: S1569-1993(19)30062-1. doi: 10.1016/j.jcf.2019.03.011
Keywords
CVD risk, Flow-mediated dilation, Reproducibility, Vascular function
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Scientific Abstract