With the CF Research News, we aim to bridge the gap between people with CF and the researchers investigating CF and how best to treat those with the condition.
We want to provide access to patients, parents, relatives, friends and caregivers of patients with CF to all scientific work mainly published in the Journal of Cystic Fibrosis (JCF).

All PDF files published hereunder are lay version summaries of work published in the JCF.

February 2025

Title: How people with CF access CFTR modulators in countries where coverage is not provided by health systems
Authors
Jonathan Guo, Grace Hennessy, Benedict Young, Andrew Hill
References
J Cyst Fibros. 2025 Feb 21:S1569-1993(25)00057-8. doi: 10.1016/j.jcf.2025.02.010.
Keywords
CFTR modulator, ETI, Elexacaftor/tezacaftor/ivacaftor, Kaftrio, Trikafta
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Scientific Abstract

February 2025

Title: Reassurance in Pregnancy and Cystic Fibrosis
Authors
Paul K Mohabir, Fatma Gunturkun, Jennifer Cannon, Yaowei Deng, Ariadna Garcia, Eahsan Shahriary, Alicia Mirza
References
J Cyst Fibros. 2025 Feb 20:S1569-1993(25)00053-0. doi: 10.1016/j.jcf.2025.02.004.
Keywords
Lung function, Outcomes, pregnancy, Survival
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Scientific Abstract

February 2025

Title: Response to CFTR modulators of the rare CFTR variants L383S, I507del, L1065P and R1066H
Authors
Jessica Conti, Dora Angyal, Karina Kleinfelder, Roberta Valeria Latorre, Martina Calicchia, Alessia Farinazzo, Luca Rodella, Francesco Tomba, Arianna Massella, Luca Frulloni, Giovanni Taccetti, Vito Terlizzi, Anny Leung, Tessa A Groeneweg,, Marcel J C Bijvelds, Paola Melotti, Claudio Sorio
References
J Cyst Fibros. 2025 Feb 19:S1569-1993(25)00059-1. doi: 10.1016/j.jcf.2025.02.008.
Keywords
CFTR variants, Bicarbonate secretion, Personalized medicine, Rectal organoids, Theratyping, Ussing chamber
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Scientific Abstract

February 2025

Title: Viral infection causes an extreme immune response and loss of cilia function in airway cells of people with CF
Authors
Jennifer A Bartlett, Eric D Huntemann, Sateesh Krishnamurthy, Stacey M Hartwig, Alvin Pewa, Andrew L Thurman, Michael S Chimenti, Eric B Taylor, Steven M Varga, Paul B McCray Jr Antiviral, Cilia, Interferon, RNAseq, Viral infection
References
J Cyst Fibros. 2025 Feb 15:S1569-1993(25)00055-4. doi: 10.1016/j.jcf.2025.02.003.
Keywords
Antiviral, Cilia, Interferon, RNAseq, Viral infection
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Scientific Abstract

February 2025

Title: Changes in how immune cells and lung cells communicate in people with cystic fibrosis
Authors
Marijn Berg, Lisette Krabbendam, Esmee K van der Ploeg, Menno van Nimwegen, Tjeerd van der Veer, Martin Banchero, Orestes A Carpaij, Remco Hoogenboezem, Maarten van den Berge, Eric Bindels, Joachim G J V Aerts, Antoine Collin, Pascal Barbry,, Lieke S Kamphuis, Rudi W Hendriks, Martijn C Nawijn, Ralph Stadhouders
References
J Cyst Fibros. 2025 Feb 12:S1569-1993(25)00049-9. doi: 10.1016/j.jcf.2025.01.016.
Keywords
Bronchial biopsies, Single-cell RNA-sequencing, structural-immune cell crosstalk
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Scientific Abstract

February 2025

Title: The relationship between ivacaftor and lung function variability
Authors
Rhonda D Szczesniak, Eleni-Rosalina Andrinopoulou, Hancheng Li, Raksha Jain, Nicole Mayer-Hamblett, Josh Ostrenga, Anushka K Palipana, David J Pasta, Margaret Rosenfeld, Jonathan Todd, Elizabeth A Cromwell, Wayne J Morgan
References
J Cyst Fibros. 2025 Feb 9:S1569-1993(25)00047-5. doi: 10.1016/j.jcf.2025.01.014.
Keywords
FEV1, Highly effective modulator, Longitudinal, mutation, patient registry, Stability
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Scientific Abstract