With the CF Research News, we aim to bridge the gap between people with CF and the researchers investigating CF and how best to treat those with the condition.
We want to provide access to patients, parents, relatives, friends and caregivers of patients with CF to all scientific work mainly published in the Journal of Cystic Fibrosis (JCF).

All PDF files published hereunder are lay version summaries of work published in the JCF.

May 2020

Title: A longitudinal assessment of non-Invasive biomarkers to diagnose and predict Ccystic Fibrosis-Associated Liver Disease
Authors
Wikrom Karnsakul, Paul Wasuwanich, Thammasin Ingviya, Alexandra Vasilescu, Kathryn A Carson, Peter J Mogayzel, Kathleen B Schwarz
References
J Cyst Fibros . 2020 May 30;S1569-1993(20)30133-8. doi: 10.1016/j.jcf.2020.05.002.
Keywords
blood chemical analysis, blood platelets, liver cirrhosis, respiratory tract infections, transferases
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Scientific Abstract
Title: Disruption of the extracellular polymeric network of Pseudomonas aeruginosa biofilms by alginate lyase enhances pathogen eradication by antibiotics
Authors
Said Daboor, John Rohde, Zhenyu Cheng
References
J Cyst Fibros . 2020 May 30;S1569-1993(20)30119-3. doi: 10.1016/j.jcf.2020.04.006.
 
Keywords
Alginate lyase, Antibiotics, Biofilm, Pseudomonas aeruginosa
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Scientific Abstract
Title: Metabolomics profiling of tobacco exposure in children with cystic fibrosis
Authors
Benjamin L. Wisniewski, Chandra L. Shrestha, Shuzhong Zhang, Rohan Thompson, Myron Gross, Judith A. Groner, Karan Uppal, Octavio Ramilo, Asuncion Mejias, and Benjamin T. Kopp
References
J Cyst Fibros . 2020 May 30;S1569-1993(20)30134-X. doi: 10.1016/j.jcf.2020.05.003.
Keywords
Metabolites, Tobacco
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Scientific Abstract

May 2020

Title: Circulating CRP and calprotectin to diagnose CF pulmonary exacerbations
Authors
David Jung, Kang Dong, Jiah Jang, Grace Y. Lam, Pearce G. Wilcox, Bradley S. Quon
References
J Cyst Fibros. 2020 May 28;S1569-1993(20)30129-6. doi: 10.1016/j.jcf.2020.04.016.
Keywords
Biomarkers, Diagnosis, Exacerbations, Inflammation
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Scientific Abstract

May 2020

Title: Testicular Pain Following Initiation of Elexacaftor/Tezacaftor/Ivacaftor in Males With Cystic Fibrosis
Authors
Shannon M Rotolo, Stephanie Duehlmeyer, Sarah M Slack, Hollyann R Jacobs, Brian Heckman
References
J Cyst Fibros. 2020 May 26;S1569-1993(20)30130-2. doi: 10.1016/j.jcf.2020.04.017
Keywords
Adverse reactions, Congenital bilateral absence of the vas deferens, Drug-related side effects, Elexacaftor, Infertility, Male
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Scientific Abstract

May 2020

Title: Global assessment of the integrated stress response in CF patient-derived airway and intestinal tissues
Authors
Giovana B. Bampi, Robert Rauscher, Sebastian Kirchner, Kathryn E. Oliver, Marcel J.C. Bijvelds, Leonardo A. Santos, Johannes Wagner, Raymond A. Frizzell, Hugo R. de Jonge, Eric J. Sorscher, Zoya Ignatova
References
J Cyst Fibros. 2020 May 22;S1569-1993(20)30118-1. doi: 10.1016/j.jcf.2020.04.005.
Keywords
ER stress, F508del-CFTR, Inflammation, RNA-seq, Tissue remodeling, Unfolded protein response (UPR)
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Scientific Abstract

May 2020

Title: Females with Cystic Fibrosis have a larger decrease in sweat chloride in response to lumacaftor/ivacaftor compared to males
Authors
B L Aalbers, R W Hofland, I Bronsveld, K M de Winter-de Groot, H G M Arets, A C de Kiviet, M M M van Oirschot-van de Ven, M A Kruijswijk, S Schotman, S Michel, C K van der Ent, H G M Heijerman
References
J Cyst Fibros. 2020 May 21;S1569-1993(20)30135-1. doi: 10.1016/j.jcf.2020.05.004
Keywords
BMI, CFTR modulators, Lumacaftor/ivacator, sweat chloride, Sweat test, Treatment response, ppFEV1
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Scientific Abstract

May 2020

Title: Distal Intestinal Obstruction Syndrome resolved by dissolution with Coca-Cola® via colonoscopy in a cystic fibrosis patient
Authors
Carlos Ferre-Aracil, Mariano González-Haba, Beatriz Tormo-Lanseros, Luis Giménez-Alvira, Manuel Jiménez-Garrido
References
J Cyst Fibros . 2020 May 20;S1569-1993(20)30132-6. doi: 10.1016/j.jcf.2020.05.001. Online ahead of print. 
Keywords
Coca-Cola®, Distal intestinal obstruction syndrome, Fecal impaction, therapy
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Scientific Abstract

May 2020

Title: Multivariate joint modeling to identify markers of growth and lung function decline that predict cystic fibrosis pulmonary exacerbation onset
Authors
E R Andrinopoulou, J P Clancy, R D Szczesniak
References
BMC Pulm Med. 2020 May 19;20(1):142. doi: 10.1186/s12890-020-1177-z.
Keywords
Dynamic prediction, functional data analysis, Medical monitoring, Multivariate longitudinal data, Registry analysis, Time-to-event
Theme
Care of patients with CF, Pulmonology
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Scientific Abstract
Title: Glucose ingestion in cystic fibrosis induces severe redox imbalance: a potential role in diabetes
Authors
William R. Hunt, Jason M. Hansen, Arlene A. Stecenko
References
J Cyst Fibros. 2020 May;19(3):476-482. doi: 10.1016/j.jcf.2020.02.010. Epub 2020 Feb 27.
Keywords
Cystic fibrosis-related diabetes, Redox
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Scientific Abstract
Title: Effect of one-year lumacaftor-ivacaftor treatment on glucose tolerance abnormalities in cystic fibrosis patients
Authors
Bastien Misgault, Eva Chatron, Quitterie Reynaud, Sandrine Touzet, Michel Abely, Laurent Melly, Stéphane Dominique, Françoise Troussier, Olivia Ronsin-Pradel, Michèle Gerardin, Julie Mankikian, Laure Cosson, Raphael Chiron, Leila Bounyar, Michel Porzio, Isabelle Durieu, Laurence Weiss, Romain Kessler, Laurence Kessler
References
J Cyst Fibros . 2020 Mar 19;S1569-1993(20)30073-4. doi: 10.1016/j.jcf.2020.03.002.
Keywords
CFTR corrector and potentiator, Glucose tolerance abnormalities, OGTT
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Scientific Abstract

May 2020

Title: Average Rate of Lung Function Decline in Adults with Cystic Fibrosis in the United Kingdom: Data from the UK CF Registry
Authors
L Caley, L Smith, H White, D G Peckham
References
J Cyst Fibros. 2020 May 4;S1569-1993(20)30121-1. doi: 10.1016/j.jcf.2020.04.008.
Keywords
Lung function, Rate of decline
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Scientific Abstract

May 2020

Title: Genetic Modifiers of Cystic Fibrosis-Related Diabetes Have Extensive Overlap With Type 2 Diabetes and Related Traits
Authors
Melis A Aksit, Rhonda G Pace, Briana Vecchio-Pagán, Hua Ling, Johanna M Rommens Pierre-Yves Boelle, Loic Guillot, Karen S Raraigh, Elizabeth Pugh, Peng Zhang, Lisa J Strug, Mitch L Drumm, Michael R Knowles, Garry R Cutting, Harriet Corvol, Scott M Blackma
References
J Clin Endocrinol Metab. 2020 May 1;105(5):1401-1415. doi: 10.1210/clinem/dgz102.
Theme
Diabetes
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Scientific Abstract