With the CF Research News, we aim to bridge the gap between people with CF and the researchers investigating CF and how best to treat those with the condition.
We want to provide access to patients, parents, relatives, friends and caregivers of patients with CF to all scientific work mainly published in the Journal of Cystic Fibrosis (JCF).

All PDF files published hereunder are lay version summaries of work published in the JCF.

February 2022

Title: Evaluation of a novel compound, AZD5634, in healthy volunteers and patients with cystic fibrosis
Authors
Cecilia Kristensson, Annika Åstrand, Scott Donaldson, Ron Goldwater, Raolat Abdulai, Naimish Patel, Philip Gardiner, Ulrika Tehler, Anne-Kristina Mercier, Marita Olsson, Eva Ersdal, Jukka Mäenpää, Tobias Bramer, Anna Malmgren, William Bennett,, Christina Keen
References
J Cyst Fibros. 2022 Feb 26;S1569-1993(22)00042-X. doi: 10.1016/j.jcf.2022.02.010.
Keywords
ENaC inhibitors, clinical trials, Mucociliary clearance, Pharmacokinetics
Theme
Clinical Trials, Pulmonology
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Scientific Abstract

February 2022

Title: The impact of the first wave of the COVID-19 pandemic on people with cystic fibrosis in New York
Authors
Joseph L Simonson, Christine Esposito, Theresa Frantzen, Katherine Henthorne, Aileen Espinal, Serena Romano, Ramona Ramdeo, Jessica Trentacoste, Donna Tsang, Geralyn LaVecchia, Robert Abdullah, Maria Berdella, Lynn Bonitz, Rany Condos,, Andrei Constantinescu, Joan K DeCelie-Germana, Emily DiMango, Myah Draine, Tara Gimeli, Robert Giusti, Jessenia Guzman, Soumia Hammouda, Claire Keating, Catherine Kier, Alison T Lennox, Carmen Liriano, Zachary Messer, Amy Plachta, Hossein Sadeghi, , Elinor Schwind, Teresa Stables-Carney, Patricia Walker, Janice Wang
References
J Cyst Fibros. 2022 Feb 21;S1569-1993(22)00044-3. doi: 10.1016/j.jcf.2022.02.012.
Keywords
Coronavirus, Covid-19 SARS-CoV2
Theme
Care of patients with CF, Lung Disease and Infection, Psychosocial
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Scientific Abstract

February 2022

Title: Human airway cell models to study genes contributing to CF lung disease
Authors
Gengming He, Naim Panjwani, Julie Avolio, Hong Ouyang, Shaf Keshavjee, Johanna M. Rommens, Tanja Gonska, Theo J. Moraes, Lisa J. Strug
References
J Cyst Fibros. 2022 Feb 18;S1569-1993(22)00039-X. doi: 10.1016/j.jcf.2022.02.007.
Keywords
Co-expression relationships, Cystic fibrosis modifier genes, Differential expression analysis, Epithelia, Equivalence testing
Theme
CFTR/Basic Science
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Scientific Abstract
Title: Tezacaftor/Ivacaftor in Children ≥6 Years of Age With F508del and Residual Function Changes in CFTR.
Authors
Gregory S Sawicki, Mark Chilvers, John McNamara, Lutz Naehrlich, Clare Saunders, Isabelle Sermet-Gaudelus, Claire E Wainwright, Neil Ahluwalia, Daniel Campbell, R Scott Harris, Hildegarde Paz-Diaz, Judy L Shih, Jane C Davies
References
J Cyst Fibros. 2022 Feb 18;S1569-1993(22)00033-9. doi: 10.1016/j.jcf.2022.02.003.
 
Keywords
Ivacaftor, Tezacaftor
Theme
Care of patients with CF, Clinical Trials, Pulmonology
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Scientific Abstract

February 2022

Title: Measuring CFTR function and relating it to health.
Authors
Jeffrey J Wine
References
J Cyst Fibros. 2022 Feb 17;S1569-1993(22)00035-2. doi: 10.1016/j.jcf.2022.02.001.
Theme
Care of patients with CF
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Scientific Abstract

February 2022

Title: Health Changes in People with CF the Year After Having a Child
Authors
Traci M. Kazmerski, Raksha Jain, MinJae Lee, Jennifer L. Taylor-Cousar
References
J Cyst Fibros. 2022 Feb 15;S1569-1993(22)00038-8. doi: 10.1016/j.jcf.2022.02.006.
Keywords
Fatherhood, Motherhood, Parenthood, pregnancy
Theme
Care of patients with CF, Pregnancy with CF, Pulmonology
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Scientific Abstract

February 2022

Title: Men’s Sexual and Reproductive Health in Cystic Fibrosis in the Era Highly Effective Modulator Therapies: A Qualitative Study
Authors
Alison R Clarke, Olivia M Stransky, Miriam Bernard, Kara S Hughan, Sigrid Ladores, Gregory S Sawicki, Michael S Stalvey, Traci M Kazmerski
References
J Cyst Fibros. 2022 Feb 12;S1569-1993(22)00034-0. doi: 10.1016/j.jcf.2022.02.002.
 
Keywords
Assisted reproductive technology, Infertility, Masculinity, Sexual and reproductive health
Theme
Care of patients with CF, Psychosocial
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Scientific Abstract
Title: CFTR modulator therapy alters sphingolipid profiles in blood from people with cystic fibrosis
Authors
Dirk Westhölter, Fabian Schumacher, Nuria Wülfinghoff, Sivagurunathan Sutharsan, Svenja Strassburg, Burkhard Kleuser, Peter A Horn, Sebastian Reuter, Erich Gulbins, Christian Taube1, Matthias Welsner
References
J Cyst Fibros. 2022 Feb 12;S1569-1993(22)00037-6. doi: 10.1016/j.jcf.2022.02.005.
Keywords
CFTR modulator therapy, Ceramide, Elexacaftor/tezacaftor/ivacaftor, Plasma sphingolipids
Theme
Nutrition/Gastroenterology
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Scientific Abstract
Title: Cystic fibrosis outcomes with Tricare Insurance
Authors
Joseph M Collaco, Lori L Vanscoy, Kevin J Psoter, Kristin A Riekert, Kimberly M Dickinson
References
J Cyst Fibros. 2022 Feb 12;S1569-1993(22)00036-4. doi: 10.1016/j.jcf.2022.02.004.
 
Theme
Care of patients with CF, Psychosocial
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Scientific Abstract

February 2022

Title: Worldwide Estimates of Cystic Fibrosis Diagnosis and Treatment Access
Authors
Jonathan Guo, Anna Garratt, Andrew Hill
References
J Cyst Fibros. 2022 Feb 3;S1569-1993(22)00031-5. doi: 10.1016/j.jcf.2022.01.009.
Keywords
CFTR modulator, Cystic fibrosis transmembrane conductance regulator, Epidemiology, Ivacaftor/tezacaftor/elexacaftor, Treatment cascade, Trikafta
Theme
Care of patients with CF, Diagnosis/Screening, Epidemiology/Models of care
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Scientific Abstract

February 2022

Title: Elexacaftor-tezacaftor-ivacaftor provides continued health improvement in lung transplant candidates with cystic fibrosis
Authors
Clémence Martin, Martine Reynaud-Gaubert, Rebecca Hamidfar, Isabelle Durieu, Marlène Murris-Espin, Isabelle Danner-Boucher, Raphaël Chiron, Sylvie Leroy, Benoit Douvry, Dominique Grenet, Laurent Mely, Sophie Ramel, Sylvie Montcouquiol, Lydie Lemonnier, , Espérie Burnet, Jean-Louis Paillasseur, Jennifer Da Silva, Pierre-Régis Burgel
References
J Cyst Fibros. 2022 Feb 2;S1569-1993(22)00032-7. doi: 10.1016/j.jcf.2022.01.012.
Theme
Care of patients with CF, Transplantation
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Scientific Abstract