With the CF Research News, we aim to bridge the gap between people with CF and the researchers investigating CF and how best to treat those with the condition.
We want to provide access to patients, parents, relatives, friends and caregivers of patients with CF to all scientific work mainly published in the Journal of Cystic Fibrosis (JCF).

All PDF files published hereunder are lay version summaries of work published in the JCF.

March 2025

Title: How sweat chloride levels relate to health improvements with CFTR modulators
Authors
Edith T Zemanick, Bonnie Ramsey, Dorota Sands, Edward F McKone, Isabelle Fajac, Jennifer L Taylor-Cousar, Marcus A Mall, Michael W Konstan, Nitin Nair, Jiaqiang Zhu, Emilio Arteaga-Solis, Fredrick Van Goor, Lisa McGarry, Valentin Prieto-Centurion,, Patrick R Sosnay, Carmen Bozic, David Waltz, Nicole Mayer-Hamblett
References
J Cyst Fibros. 2025 Mar;24(2):246-254. doi: 10.1016/j.jcf.2024.12.006. Epub 2025 Jan 3.
Keywords
CFTR function, CFTR modulators, clinical outcomes, sweat chloride
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Scientific Abstract
Title: AI-Powered Home Monitoring for Cystic Fibrosis Flare-Ups in Kids and Adults
Authors
Henryk Mazurek, Andrzej Emeryk, Kamil Janeczek, Eric Derom, Barbara Kuźnar-Kamińska, Tomasz Grzywalski, Adam Biniakowski, Krzysztof Szarzyński, Anna Pastusiak, Dominika Kaminiarczyk-Pyzałka, Dick Botteldooren, Honorata Hafke-Dys, Jędrzej Kociński
References
J Cyst Fibros. 2025 Mar;24(2):390-397. doi: 10.1016/j.jcf.2025.02.011. Epub 2025 Feb 18.
Keywords
AI-aided CF management, Cystic fibrosis exacerbation, Cystic fibrosis monitoring, Remote management of CF, hOme healthcare
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Scientific Abstract
Title: Mental health is related to adherence through self-efficacy and perceived barriers
Authors
Robin S Everhart, Milene T Saavedra, Christine R Ford, Sidney L Gibson, Felicia Reid, Emily F Muther, Christina L Duncan, Rachel Cravens, Angela Green, Kristin A Riekert
References
J Cyst Fibros. 2025 Mar;24(2):334-340. doi: 10.1016/j.jcf.2025.02.016. Epub 2025 Feb 22.
Keywords
Adherence, Barriers, mental health, Self-efficacy
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Scientific Abstract

March 2025

Title: Treating cystic fibrosis before birth: What we learned from an unsuccessful case
Authors
M Destoop, C Brantner, E B Wilms, Shaj Tytgat, B Peels, R van der Graaf, T B Y Liem, K M de Winter-de Groot
References
J Cyst Fibros. 2025 Mar 20:S1569-1993(25)00074-8. doi: 10.1016/j.jcf.2025.03.006.
Keywords
CFTR modulator therapy, In utero exposure, meconium ileus, pregnancy
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Scientific Abstract

March 2025

Title: Drug allergy to CFTR modulators – an international survey
Authors
Ruth M Urbantat, Laura Behan, Sebastian Wisniewski, Joshua Gardner, Mirjam Stahl, Marcus A Mall, Daniel Peckham, Dean J Naisbitt, Jobst F Roehmel
References
J Cyst Fibros. 2025 Mar 18:S1569-1993(25)00071-2. doi: 10.1016/j.jcf.2025.03.003.
Keywords
CFTR modulator withdrawal, Drug allergy, Drug allergy to CFTR modulator therapy, Immunogenic adverse events, Real-world data
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Scientific Abstract

March 2025

Title: Tracking the journey of elexacaftor-tezacaftor-ivacaftor in the bodies of children with cystic fibrosis
Authors
Steffie E M Vonk, Suzanne W J Terheggen-Lagro, Eric G Haarman, S Hashimoto, Anke H Maitland-van der Zee, Ron A A Mathôt, E Marleen Kemper; Amsterdam Mucociliary Clearance Disease (AMCD) research group
References
J Cyst Fibros. 2025 Mar 14:S1569-1993(25)00076-1. doi: 10.1016/j.jcf.2025.03.008.
Keywords
CFTR modulators, Elexacaftor-tezacaftor-ivacaftor, Pediatrics, Population
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Scientific Abstract

March 2025

Title: Lower inflammation is related to greater energy levels in adults with cystic fibrosis on elexacaftor/tezacaftor/ivacaftor
Authors
Jacob Gravelle, Sameer Desai, Kang Dong, Bradley S Quon
References
J Cyst Fibros. 2025 Mar 11:S1569-1993(25)00073-6. doi: 10.1016/j.jcf.2025.03.004.
Keywords
Elexacaftor, Fatigue, Systemic inflammation, Vitality
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Scientific Abstract

March 2025

Title: Do people with cystic fibrosis experience side effects from Elexacaftor/Tezacaftor/Ivacaftor because of high drug levels?
Authors
Syendon B C Baromeo, Renske van der Meer, Richard C J M van Rossen, Erik B Wilms
References
J Cyst Fibros. 2025 Mar 10:S1569-1993(25)00061-X. doi: 10.1016/j.jcf.2025.02.013.
Keywords
adverse events, Dose reduction, Drug concentration levels, Elexacaftor/tezacaftor/ivacaftor, Pharmacology
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Scientific Abstract

March 2025

Title: CFTR modulators and pregnancy outcomes: early findings from a nationwide cohort study
Authors
Laurent Chouchana, Mathis Collier, Clémence Martin, Pierre-Régis Burgel, Jean-Marc Treluyer
References
J Cyst Fibros. 2025 Mar 8:S1569-1993(25)00070-0. doi: 10.1016/j.jcf.2025.03.002.
Keywords
Birth defect, CFTR modulators, Drug safety, pregnancy, fetus
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Scientific Abstract