CF Research News for July 2023 | European Cystic Fibrosis Society (ECFS)

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With the CF Research News, we aim to bridge the gap between people with CF and the researchers investigating CF and how best to treat those with the condition.
We want to provide access to patients, parents, relatives, friends and caregivers of patients with CF to all scientific work mainly published in the Journal of Cystic Fibrosis (JCF).

All PDF files published hereunder are lay version summaries of work published in the JCF.

July 2023

Title: A Search Begins for the Role of CircRNAs in Cystic Fibrosis

Authors

Edward A Salinas, Victor Macauley, Kim M Keeling, Yvonne J K Edwards

References

J Cyst Fibros. 2023 Jul;22(4):683-693. doi: 10.1016/j.jcf.2023.04.021. Epub 2023 May 2

Keywords

CircRNAflow, Circular RNA, Computational biology pipeline, Cystic fibrosis-related diabetes, Nextflow, Putative biomarkers, Whole blood transcriptome sequencing analyses

CF Research News Article

Scientific Abstract

Title: Improvement of Pulmonary Function After Implementation of a Standardized Cystic Fibrosis Care Algorithm

Authors

Yasemin Gokdemir, Ela Erdem Eralp, Almala Pinar Ergenekon, Cansu Yilmaz Yegit, Muruvvet Yanaz, Hakan Mursaloğlu, Burcu Uzunoglu, Damla Kocamaz, Gamze Tastan, Ozge Kenis Coskun, Amy Filbrun, Catherine Enochs, Sandra Bouma , Courtney Iwanicki, Fazilet Karak

References

J Cyst Fibros. 2023 Jul;22(4):710-714. doi: 10.1016/j.jcf.2023.03.016. Epub 2023 Apr 8.

Keywords

Children, Lung function, quality improvement

CF Research News Article

Scientific Abstract

Title: Bacterial infections and the antibiotics prescribed for children with cystic fibrosis-related pulmonary exacerbations

Authors

Anna V Faino, Lucas R Hoffman, Ronald L Gibson, Matthew P Kronman, David P Nichols, Margaret Rosenfeld, Jonathan D Cogen

References

J Cyst Fibros. 2023 Jul;22(4):630-635. doi: 10.1016/j.jcf.2023.02.001. Epub 2023 Feb 26.

CF Research News Article

Scientific Abstract

July 2023

Title: Response to oral antibiotic treatment in people with cystic fibrosis

Authors

Ana Blanchard, Michelle Shaw, Felix Ratjen, Elizabeth Tullis, Nick Daneman, Valerie Waters

References

J Cyst Fibros. 2023 Jul 18;S1569-1993(23)00829-9. doi: 10.1016/j.jcf.2023.06.015.

Keywords

oral antibiotics, Pulmonary exacerbation

Theme

Care of patients with CF, Lung Disease and Infection

CF Research News Article

Scientific Abstract

July 2023

Title: Comparing how effective and safe 14 days and 28 days of inhaled aztreonam were at getting rid of a Pseudomonas bacterial lung infection.

Authors

Francis J Gilchrist, Stephanie Bui, Silvia Gartner, Susanna A McColley, Harm Tiddens, Gary Ruiz, Florian Stehling, Muhsen Alani, Oksana Gurtovaya, Mark Bresnik, Timothy R Watkins, Biliana Frankovic, Marianne Skov; ALPINE2 study investigators

References

J Cyst Fibros. 2023 Jul 14:S1569-1993(23)00821-4. doi: 10.1016/j.jcf.2023.06.008.

Keywords

Aztreonam, eradication, Paediatric, Pseudomonas aeruginosa, Respiratory infections

CF Research News Article

Scientific Abstract

July 2023

Title: CFTR modulator therapy may improve lipid levels in children and adolescents with cystic fibrosis.

Authors

Tatiana Yuzyuk, Catherine M McDonald, Lauren M Zuromski, Irene De Biase, Lisa Johnson, Nicole Williams, Suzanne Meihls, Fadi Asfour

References

J Cyst Fibros. 2023 Jul 13:S1569-1993(23)00831-7. doi: 10.1016/j.jcf.2023.07.001.

Keywords

CFTR modulators, Lipids, Lipoproteins

CF Research News Article

Scientific Abstract

July 2023

Title: Ivacaftor impacts nutrition and growth status in 4 to 24 month old children within the first 12 weeks

Authors

Alyssa Tindall, Rosara Bass, Asim Maqbool, Virginia A Stallings

References

J Cyst Fibros. 2023 Jul 10;S1569-1993(23)00114-5. doi: 10.1016/j.jcf.2023.04.010.

Keywords

Bile acids, Fatty acids, Ivacaftor, nutritional status

Theme

Care of patients with CF, Nutrition/Gastroenterology

CF Research News Article

Scientific Abstract

July 2023

Title: Successful treatment of a blockage in the lower portion of the small intestine in patients with cystic fibrosis using a solution administered during a colonoscopy.

Authors

Ikenna K Emelogu, Cynthia N Tran, Wendy R Greene, Joshua D Novak

References

J Cyst Fibros. 2023 Jul 8;S1569-1993(23)00828-7. doi: 10.1016/j.jcf.2023.06.014

Keywords

colonoscopy, DIOS, Distal intestinal obstruction syndrome, N-acetylcysteine, Polyethylene glycol

Theme

Care of patients with CF, Imaging, Nutrition/Gastroenterology

CF Research News Article

Scientific Abstract

July 2023

Title: CF Mutation Presents with Intestinal Obstruction in Newborns and Later Pancreatic Sufficiency

Authors

Emma Lang, Bridget Kiernan, Eleanor D. Muise, Robert Giusti

References

J Cyst Fibros. 2023 Jul 7;S1569-1993(23)00045-0. doi: 10.1016/j.jcf.2023.02.002.

Theme

Care of patients with CF, Diagnosis/Screening, Newborn screening

CF Research News Article

Scientific Abstract

July 2023

Title: STOP Codon mutations are associated with more severe disease from childhood in people with cystic fibrosis

Authors

Annalisa Orenti, Iwona Pranke, Caroline Faucon, Jessica Varilh, Aurelie Hatton, Anita Golec, Clemence Dehillotte, Isabelle Durieu, Philippe Reix, Pierre-Régis Burgel, Dominique Grenet, Céline Tasset, Elsa Gachelin, Caroline Perisson, Agathe Lepissier, , Elise Dreano, Danielle Tondelier, Benoit Chevalier, Laurence Weiss, Sébastien Kiefer, Muriel Laurans, Raphael Chiron, Lydie Lemonnier, Christophe Marguet, Andreas Jung, Aleksander Edelman, Bat-Sheva Kerem, Emmanuelle Girodon, Magali Taulan-Cadars,, Alexandre Hinzpeter, Eitan Kerem, Lutz Naehrlich, Isabelle Sermet-Gaudelus; ECFSPR Steering group

References

J Cyst Fibros. 2023 Jul 6:S1569-1993(23)00819-6. doi: 10.1016/j.jcf.2023.06.005.

Keywords

MeSH: DO008550, Cystic fibrosis transmembrane conductance regulator (MeSH: DO19005), Premature termination codon (MeSH: DO:18389)

CF Research News Article

Scientific Abstract

Title: Changes in weight and how much you eat after starting triple modulator therapy in adults with cystic fibrosis

Authors

L R Caley, H H Jarosz-Griffiths, L Smith, L Gale, J Barrett, L Kinsey, V Davey, M Nash, A M Jones, J L Whitehouse, D Shimmin, R A Floto, H White, D G Peckham

References

J Cyst Fibros. 2023 Jul 6;S1569-1993(23)00824-X. doi: 10.1016/j.jcf.2023.06.010.

Keywords

Body mass index, CFTR modulators, Elexacaftor/ivacaftor/tezacaftor, Energy expenditure, Nutritional intake

Theme

Nutrition/Gastroenterology

CF Research News Article

Scientific Abstract

Title: Airway infection increases Pseudomonas aeruginosa acquisition

Authors

Julie Mésinèle, Manon Ruffin, Loïc Guillot, Pierre-Yves Boëlle, Harriet Corvol

References