With the CF Research News, we aim to bridge the gap between people with CF and the researchers investigating CF and how best to treat those with the condition.
We want to provide access to patients, parents, relatives, friends and caregivers of patients with CF to all scientific work mainly published in the Journal of Cystic Fibrosis (JCF).

All PDF files published hereunder are lay version summaries of work published in the JCF.

February 2021

Title: “Il faut continuer à poser des questions” patient reported outcome measures in cystic fibrosis: An anthropological perspective
Authors
Rosa Coucke, Audrey Chansard, Véronique Bontemps, Dominique Grenet, Dominique Hubert, Clémence Martin, Elise Lammertyn, Emmanuelle Bardin, Veerle Bulteel, Frédérique Chedevergne, Muriel Le Bourgeois, Pierre-Régis Burgel, Isabelle Honore, Hilde de Keyser, Maya Kirszenbaum, Paola de Carli, Isabelle Sermet-Gaudelus, Kate Hayes, European Cystic Fibrosis Society-Clinical Trials Network Patient Advisory Group
References
J Cyst Fibros. 2021 Feb 26;S1569-1993(21)00044-8. doi: 10.1016/j.jcf.2021.02.009.
 
Keywords
Patient reported outcome measures, Patient-led research
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Scientific Abstract
Title: Limb muscle size and contractile function in adults with cystic fibrosis: A systematic review and meta-analysis
Authors
Kenneth Wu, Polyana L Mendes, Jenna Sykes, Anne L Stephenson, Sunita Mathur
References
J Cyst Fibros. 2021 Feb 26;S1569-1993(21)00045-X. doi: 10.1016/j.jcf.2021.02.010
Keywords
Adult, Muscle weakness, Muscular atrophy, Skeletal muscle
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Scientific Abstract

February 2021

Title: Defining key outcomes to evaluate performance of newborn screening programmes for cystic fibrosis
Authors
Anne Munck, Kevin W Southern, Carlo Castellani, Karin M de Winter-de Groot, Silvia Gartner, Nataliya Kashirskaya, Barry Linnane, Sarah J Mayell, Marijke Proesmans, Dorota Sands, Olaf Sommerburg, Jürg Barben, European CF Society Neonatal Screening Working
References
J Cyst Fibros. 2021 Feb 23;S1569-1993(21)00041-2. doi: 10.1016/j.jcf.2021.02.006.
Keywords
CFSPID, Evaluation (3–6 words), Newborn screening, Outcome
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Scientific Abstract
Title: Performing an exercise capacity test, known as the modified shuttle test, can help to detect the risk of being hospitalized in youths with cystic fibrosis
Authors
Márcio Vinícius Fagundes Donadio, Fernanda Maria Vendrusculo, Natália Evangelista Campos, Nicolas Acosta Becker, Ingrid Silveira de Almeida, Karen Caroline Vasconcelos Queiroz, Luanna Rodrigues Leite and Evanirso Silva Aquino
References
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February 2021

Title: Outcomes of cystic fibrosis pulmonary exacerbations treated with antibiotics with activity against anaerobic bacteria
Authors
Lauren M. Castner, Madsen Zimbric, Shannon Cahalan, Corey Powell, Lindsay J. Caverly
References
J Cyst Fibros. 2021 Feb 18;S1569-1993(21)00036-9. doi: 10.1016/j.jcf.2021.02.001.
Keywords
Anaerobes, Antibiotics, Exacerbations
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Scientific Abstract

February 2021

Title: Neutrophil Dysfunction in Cystic Fibrosis
Authors
Lael M. Yonker, Anika Marand,, Sinan Muldur, Alex Hopke, Hui Min Leung, Denis De La Flor , Grace Park , Hanna Pinsky , Lauren B. Guthrie , Guillermo J. Tearney, Daniel Irimia, Bryan P. Hurley
References
J Cyst Fibros. 2021 Feb 13;S1569-1993(21)00035-7. doi: 10.1016/j.jcf.2021.01.012.
Keywords
Inflammation, Micro-fluidics, Micro-optical coherence tomography, Neutrophil
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Scientific Abstract

February 2021

Title: Airways glutathione S-transferase omega-1 and inflammation in cystic fibrosis
Authors
Simona Piaggi, Elisabetta Marchi, Vittoria Carnicelli, Riccardo Zucchi, Matthias Griese, Andreas Hector, Claudio Sorio, Alfonso Pompella, Alessandro Corti
References
J Cyst Fibros. 2021 Feb 11;S1569-1993(21)00033-3. doi: 10.1016/j.jcf.2021.01.010.
Keywords
A140D polymorphism, FEV1, FEV1/FVC ratio, GSTO1-1, Glutathione S-transferase omega-1-1, Gamma-glutamyltransferase, lung inflammation
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Scientific Abstract

February 2021

Title: Measuring the impact of CFTR modulation on sweat chloride in cystic fibrosis: Rationale and design of the CHEC-SC Study
Authors
Edith T. Zemanick, Michael W. Konstan, Donald R. VanDevanter, Steven M. Rowe, JP Clancy, Katherine Odem-Davis, Michelle Skalland, Nicole Mayer-Hamblett
References
J Cyst Fibros. 2021 Feb 8;S1569-1993(21)00034-5. doi: 10.1016/j.jcf.2021.01.011.
Keywords
CFTR modulator, Ivacaftor, Lumacaftor-ivacaftor, sweat chloride, Sweat test
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Scientific Abstract

February 2021

Title: Targeting G542X CFTR Nonsense Alleles With ELX-02 Restores CFTR Function in Human-Derived Intestinal Organoids
Authors
Daniel K Crawford, Jasper Mullenders, Johanna Pott, Sylvia F Boj, Shira Landskroner-Eiger, Matthew M Goddeeris
References
J Cyst Fibros. 2021 Feb 5;S1569-1993(21)00028-X. doi: 10.1016/j.jcf.2021.01.009.
Keywords
ELX-02, NB124, Nonsense allele, Organoid, Read-through
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Scientific Abstract