With the CF Research News, we aim to bridge the gap between people with CF and the researchers investigating CF and how best to treat those with the condition.
We want to provide access to patients, parents, relatives, friends and caregivers of patients with CF to all scientific work mainly published in the Journal of Cystic Fibrosis (JCF).

All PDF files published hereunder are lay version summaries of work published in the JCF.

April 2015

Title: Randomized Trial of Efficacy and Safety of Dornase Alfa Delivered by eRapid Nebulizer in Cystic Fibrosis Patients.
Authors
Gregory S. Sawicki, Will Chou, Karina Raimundo, Ben Trzaskoma, Michael W. Konstan
References
J Cyst Fibros. 2015 Apr 25. pii: S1569-1993(15)00103-4. doi: 10.1016/j.jcf.2015.04.003
Keywords
Nebulizers, Dornase alfa
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Scientific abstract
Title: Deleterious impact of hyperglycemia on cystic fibrosis airway ion transport and epithelial repair.
Authors
Claudia Bilodeau, Olivier Bardou, Émilie Maillé, Yves Berthiaume, Emmanuelle Brochiero
References
J Cyst Fibros. 2015 Apr 24. pii: S1569-1993(15)00102-2
Keywords
Airways, Epithelial repair, K+ channels, CFTR, Cystic fibrosis, Diabetes
Theme
CFTR/Basic Science
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Scientific abstract
Title: Assessment of Epithelial Sodium Channel Variants in Nonwhite Cystic Fibrosis Patients with Non-Diagnostic CFTR Genotypes
Authors
Marie-Luise Brennan, Lynn M. Pique, Iris Schrijver
References
J Cyst Fibros. 2015 Apr 17. pii: S1569-1993(15)00101-0. doi: 10.1016/j.jcf.2015.04.001
Keywords
Epithelial sodium channel, ENaC, SCNN1, Molecular diagnosis, CFTR, Nonwhite
Theme
Diagnosis/Screening
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Scientific abstract
Title: Cystic fibrosis transmembrane conductance regulator gene variants are associated with autoimmune pancreatitis and slow response to steroid treatment.
Authors
Ming-Chu Chang, I-Shiow Jan, Po-Chin Liang, Yung-Ming Jeng, Ching-Yao Yang, Yu-Wen Tien, Jau-Min Wong, Yu-Ting Chang
References
J Cyst Fibros. 2015 Apr 10. pii: S1569-1993(15)00064-8.
Keywords
Autoimmune pancreatitis (AIP), Cystic fibrosis transmembrane conductance regulator (CFTR), Next-generation sequencing (NGS) response to steroid treatment
Theme
Nutrition/Gastroenterology
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Scientific abstract
Title: Use of ibuprofen to assess inflammatory biomarkers in induced sputum: Implications for clinical trials in cystic fibrosis.
Authors
Chmiel JF, Konstan MW, Accurso FJ, Lymp J, Mayer-Hamblett N, VanDevanter DR, Rose LM, Ramsey BW
References
J Cyst Fibros. 2015 Apr 10. pii: S1569-1993(15)00062-4. doi: 10.1016/j.jcf.2015.03.007
Keywords
Biomarkers, Induced sputum, Inflammation, Ibuprofen, Anti-inflammatory drugs
Theme
Immunology
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Scientific abstract
Title: Strain Rate Echocardiography Uncovers Subclinical Left Ventricular Dysfunction in Cystic Fibrosis.
Authors
Zachary M Sellers, Lori McGlocklin, Andrea Brasch
References
J Cyst Fibros. 2015 Apr 9. pii: S1569-1993(15)00065-X
Keywords
Left ventricle, Heart function, Echocardiography, Strain imaging
Theme
Pulmonology
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Scientific abstract