The ECFS-CTN cannot guarantee that the information provided here is comprehensive. Please go to the ClinicalTrials.gov link for detailed and up-to-date information on study background, eligibility criteria, study design, outcome measures, study status, participating sites, sponsor contact information and timelines.

You can also contact the CTN coordinating centre for additional information: ECFS-CTN@uzleuven.be

Study Name on
ClinicalTrials.gov (link is external)
A Phase 3 Study of VX-659 Combination Therapy in Subjects With Cystic Fibrosis Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF)
Study Drug VX-659 in triple combination with tezacaftor and ivacaftor 
Type of Study Drug CFTR modulator
Study Title A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-659 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF)
Study Phase 3
Study Sponsor Vertex

Link on
clinicaltrials.gov (link is external)

https://clinicaltrials.gov/ct2/show/NCT03447249

Participating ECFS-CTN sites Please contact ecfs-ctn@uzleuven.be for most recent sitelist
Age 12 years and older