Page updated 15 March 2013

Programme Overview

Wednesday 20 March 2013 - 10:00-16:00 - Special Pre-Conference Seminar - Animal Models
For this event, special registration is required as attendance will be limited.  Further information available here.

 Wednesday 20 March 2013
14:00-17:30 Registration, Light Meal
Set-up of Posters
17:30-18:00 Official Opening - Conference Chairpersons
18:00-19:00 Key Note Lecture
Innate defense, lung infection and cystic fibrosis – Michel Chignard (FR)
19:15-21:30 Welcome Cocktail and Dinner
 Thursday 21 March 2013
08:45-10:30 Symposium 1 - Pathophysiology Related to CF
Chairs: Michael Gray (UK) / Miguel Valverde (ES)
08:45-09:10 Inflammatory Responses in the Lungs of newborn cf and non-cf pigs challenged with bacteria - Paul McCray (US) 
09:10-09:35  Ethanol and Fatty Acids Strongly Inhibit the Activity of the CFTR Chloride Channel and Anion Exchangers in Pancreatic Ductal Epithelial Cells - Peter Hegyi (HU)
09:35-10:00  TRP channels relevant to epithelial physiology - Miguel Valverde (ES)
10:00-10:10  Abstract 25 : Planar Cell Polarity protein network, which controls ciliogenesis and cilia function, is altered in Human Cystic Fibrosis Bronchial Epithelial cells – Sabrina Noel (BE)
10:10-10:20  Abstract 28 : TMEM16A/ANO1 expression in human bronchial epithelia – Paolo Scudieri (IT)  
10:20-10:30  Abstract 62: Correction of bone defect in cystic fibrosis: studies from F508del CFTR human and mouse models.- Jacky Jacquot (FR)
10:30-11:00 Coffee Break and Poster Viewing
11:00-12:45 Symposium 2 - Cell Biology of CF: Autophagy and Degradation
Chairs: Margarida Amaral (PT) / Bruce Stanton (US)
11:00-11:25  Targeting autophagy as a new strategy to circumvent ?F508CFTR defect - Luigi Maiuri (IT) 
11:25-11:50  A Pseudomonas aeruginosa toxin enhances the degradation of CFTR and disrupts MHC class I antigen presentation in respiratory epithelial cells - Bruce Stanton (US) 
11:50-12:15  CFTR as a signal generator, new evidence - Anil Mehta (UK) 
12:15-12:25  Abstract 13: Palmitate accumulates within phosphatidylcholine of cystic fibrosis human bronchial epithelial cells: impact on F508del-CFTR trafficking.- Laurie-Anne Payet (FR)
12:25-12:35  Abstract 24: Modulation of epithelial repair and autophagy by female hormones in normal and cystic fibrosis human epithelial bronchial cells – Vinciane Saint Criq (IE)
12:35-12:45  Abstract 14: Exchange Proteins Directly Activated by Cyclic AMP: Novel CFTR Interactors? - João Fernandes (PT) 
12:45-14:30 Lunch
14:30-16:40 Symposium 3 - Infection, Inflammation and Immunity - I
Chairs: Michel Chignard (FR) / Giulio Cabrini (IT)
14:30-14:55  Pulmonary Phage Therapy: efficiency of bacteriophages to treat bacterial infections of cystic fibrosis patients - Laurent Debarbieux (FR)
14:55-15:20  Type IIA secretory phospholipase A2 plays a key role in elimination of Staphylococcus aureus from cystic fibrosis lung - Lhousseine Touqui (FR) 
15:20-15:45  Living without oxygen: anaerobiasis in the CF Airway - Stuart Elborn (UK)
15:45-16:10  Mucus Hyperconcentration as an initiator of infection and inflammation in CF - Ric Boucher (US)
16:10-16:20  Abstract 31: Lipoxin A4 Delays the Invasion of Cystic Fibrosis Bronchial Epithelial Cells by the pathogen Pseudomonas aeruginosa – Gerard Higgins (IE)
16:20-16:30  Abstract 40: Anti-inflammatory effect of FDA approved drugs in CF cells – Pascale Fanen (FR)
16:30-16:40  Abstract 39 Potential role of expression of E3 Ubiquitin Ligases in regulating the inflammatory phenotype of Cystic Fibrosis – Sara Canato (PT)  
16:40-17:10 Coffee Break and Poster Viewing
17:10-18:40 Special Group Discussion 1 - CFTR Gene Expression/Modifiers
Chairs: Paul McCray (US) / Harriet Corvol (FR) - more
17:10-18:40 Workshop 1 - Expression and Purification of CFTR
Chairs: Bob Ford (UK) / Christine Bear (CA) - more
20:00-21:30 Dinner
21:30-23:30  Flash Poster Session - Odd Numbers
Poster Session - Odd Numbers
 Friday 22 March 2013
08:45-10:30 Symposium 4 - CFTR Folding: Towards Correcting the Defect
Chairs: Christine Bear (CA) / Ineke Braakman (NL)
08:45-09:10  Lesson and tools from a decade of biophysical studies of CFTR nucleotide-binding domains - John Hunt (US)
09:10-09:35  Towards a rational design of combination corrector strategy to restore ?F508-CFTR coupled domain folding - Gergely Lukacs (CA)
09:35-10:00  Folding and assembly of MSD1 and NBD1 during CFTR  - Ineke braakman (NL) 
10:00-10:10  Abstract 7 : Mechanistic Studies of CFTR Correctors  - André Schmidt (US)
10:10-10:20  Abstract 4 : The Corrector C18 Modulates The Channel Activity Of Purified And Reconstituted CFTR Independent Of ATP – Paul Eckford (CA)  
10:20-10:30  Abstract 12 The iminosugar IsoLAB corrects the defective trafficking of F508del-CFTR by prevention of Hsp90/CFTR interaction – Johanna Bertrand (FR) 
10:30-11:00 Coffee Break and Poster Viewing
11:00-12:45 Symposium 5 - Infection, Inflammation and Immunity - II
Chairs: Stuart Elborn (UK) / Jean-Michel Sallenave (FR)
11:00-11:25  Phospholipase C beta and pro-inflammatory signaling in bronchial epithelial cells -Giulio Cabrini (IT) 
11:25:11:50  Modulation of inflammatory signaling by Nrf2 mediated antioxidant responses - Assem Ziady (US) 
11:50-12:15  The neutrophil in cystic fibrosis: dysregulation and inflammation - Gerry McElvaney (IE) 
12:15-12:25  Abstract 36: Neutrophil Elastase-mediated Increase in Airway Temperature during Inflammation – Annika Schmidt (DE)
12:25-12:35  Abstract 33: Classically activated macrophages promote inflammation in response to Pseudomonas aeruginosa but do not provide an effective barrier against bacterial growth – Luisa Martinez-Pomares (UK)
12:35-12:45  Abstract 38: Residence in Biofilms allows Burkholderia cepacia Complex (Bcc) Bacteria to Evade Neutrophil Anti-microbial Activities – Mark Murphy (IE) 
12:45-18:00 Lunch and Free Afternoon
18:00-19:55 Symposium 6 - CFTR Functional Interactome
Chairs: Ray Frizzell (US) / Aleksander Edelman (FR)
18:00-18:25  Small heat shock proteins target mutant CFTR for degradation via a SUMO-dependent pathway - Ray Frizzell (US) 
18:25-18:50  CFTR interactions studied in live cells - Peter Haggie (US) 
18:50-19:15  Potentiating and correcting double effect of snake venom Phospholipase A2 on ?F508-CFTR - Grazyna Faure (FR) 
19:15-19:40  cAMP compartmentalisation and regulation of CFTR - Manuella Zaccolo (UK) 
19:40-19:50  Abstract 10: Interaction between keratin 8 and Cystic Fibrosis Transmembrane Regulator (CFTR): structural studies – Anna Kupniewska (FR)
19:50-20:00  Abstract 59: A functional CFTR assay using primary cystic fibrosis intestinal organoids – Florijn Dekkers (NL)
20:00-20:10  Abstract 23: Signaling detected at ENaC N-termini controls ENaC proteolysis.- Jack Stutts (US) 
20:15-21:30  Dinner
21:30-23:30  Flash Poster Session - Even Numbers
Poster Session - Even Numbers
Saturday 23 March 2013
08:45-10:30 Symposium 7 - Mucus and CF
Chairs: Steve Ballard (US) / Gerd Döring (DE)
08:45-09:10  Airway mucin organisation and maturation - Dave Thornton (UK) 
09:10-09:35  Bicarbonate, a functional CFTR channel, and enzymatic activities are required for proper mucin secretion and link Cystic Fibrosis to its mucus phenotype - Gunnar C. Hansson (SE) 
09:35-10:00  Genesis of Thick Mucus in Cystic Fibrosis Airways - Steve Ballard (US) 
10:00-10:10  Abstract 44: Modification of the salivary secretion assay in F508del mice – Salivary Chloride Quantification – Peter Sandner (DE)
10:10-10:20  Abstract 60: Treatment with VX-809 and VX-770 in rectal CF organoids expressing uncommon CFTR genotypes – Evelien Kruisselbrink (NL) 
10:20-10:30  Abstract 26: SLC26A9-mediated Cl- Secretion Is Induced In Airway Inflammation And Prevents Mucus Obstruction In Mice – Julia Duerr (DE) 
10:30-11:00 Coffee Break
11:00-12:30 Workshop 2 - Imaging - Microscopy
Chairs: Rob Tarran (US) / Peter Haggie (US)
11:00-12:30 Special Group Discussion 2 - Correctors/Potentiators/New Treatments
Chairs: John Hanrahan (CA) / Christine Bear (CA) - more
12:30-14:00 Lunch
14:00-15:45 Symposium 8 - CFTR Structure and Function
Chairs: Oscar Moran (IT) / Bob Ford (UK)
14:00-14:25  Chimeric constructs endow the human CFTR Cl- channel with the sub-conductance state behaviour of murine CFTR - David Sheppard (UK) 
14:25-14:50  Insight into the structure, function and energetics of CFTR and its domains gained from atomic-level molecular simulations - Hanoch Senderowitz (IL) 
14:50-15:15  P-glycoprotein, CFTR, and domain unfolding/stability studies: what can we learn about membrane protein structural responses to ligand binding and interdomain cooperativity? - Christie Brouillette (US) 
15:15-15:25  Abstract 2: Generation and Characterization of The G551D Mutation in CFTR Expressed in S. Cerevisiae – Xin Meng (UK)
15:25-15:35  Abstract 3: Purification and biophysical characterization of full-length CFTR expressed in Saccharomyces cerevisiae – Natasha Cant (UK) 
15:35-15:45  Abstract 8: ICL1 Facilitates the Conformational Maturation of CFTR Through Interdomain Interfaces with NBD1 and ICL3 – Steven Molinski (CA) 
15:45-16:15 Coffee Break
16:15-18:00 Symposium 9 - CFTR and COPD/Smoking
Chairs: Hugo De Jonge (NL) / Gerry McElvaney (IE)
16:15-16:40  Cigarette Smoke Exposure and the Failure of Airway Surface Liquid Homeostasis - Rob Tarran (US) 
16:40-17:05  Acquired CFTR Dysfunction in Chronic Obstructive Pulmonary Disease - Steven Rowe (US) 
17:05-17:30  CFTR modulates onset and severity of chronic obstructive lung disease in ENaC-overexpressing mice - Marcus Mall (DE) 
17:30-17:40  Abstract 21:  SLC6A14 enhances constitutive CFTR-mediated Cl- secretion in Human non-CF and CF Primary Bronchial Epithelia – Tanja Gonska (CA)
17:40-17:50  Abstract 55 : Small Molecule Inhibitors of GSNOR Possess Anti-inflammatory and Bronchodilatory Actions in Mouse Models of Inflammatory Lung Disease and Modulate CFTR Function in F508del CFTR Mice.-  Sherif Gabriel (US) 
17:50-18:00  Abstract 5 : Functional Consequences of the I507ATC?ATT Silent Codon Change in ?F508 CFTR – Zsuzsa Bebok (US) 
18:00-18:15 Break
18:15-19:15 Key Note Lecture
Pharmacological Strategies to Rescue Chloride Transport in Cystic Fibrosis - Luis Galietta (IT)
20:30  Dinner / Social Event