December 2020
Title: Pilot study suggests that the gut bacteria in people with CF change with CFTR modulator therapy
Authors C E Pope, A T Vo, H S Hayden, E J Weiss, S Durfey, S McNamara, A Ratjen, B Grogan, S Carter, L Nay, M R Parsek, P K Singh, E F McKone, M L Aitken, M R Rosenfeld, L R Hoffman
References J Cyst Fibros. 2020 Dec 31;S1569-1993(20)30934-6. doi: 10.1016/j.jcf.2020.12.002.
Keywords Antibiotics, CFTR modulators, Dysbiosis, Fecal microbiome
December 2020
Title: Men's health in the modern era of cystic fibrosis
Authors F N Khan, V Tangpricha, K S Hughan, R Jain, S L Ladores, J L Taylor-Cousar, N E West, K Montemayor, G S Sawicki, A Uluer, M L Aitken, M Shnorhavorian, L A Bray, C Kvam, M Stalvey, T M Kazmerski
References J Cyst Fibros. 2020 Dec 26;S1569-1993(20)30945-0. doi: 10.1016/j.jcf.2020.12.013.
December 2020
Title: Psychological distress in adults with and without cystic fibrosis during the COVID-19 lockdown
Authors Riccardo Ciprandi, Maurizio Bonati, Rita Campi, Rita Pescini, Carlo Castellani
References J Cyst Fibros. 2020 Dec 23;S1569-1993(20)30948-6. doi: 10.1016/j.jcf.2020.12.016.
Keywords anxiety, COVID-19, depression, Pandemics, Psychosocial distress
December 2020
Title: Elexacafator/tezacaftor/ivacaftor Resolves Subfertility in Females with CF: A Two Center Case Series
Authors Kate E O'Connor, Dana L Goodwin, Andrew NeSmith, Bryan Garcia, Christina Mingora, Sigrid L Ladores, Steve M Rowe, Stefanie Krick, George M Solomon
References J Cyst Fibros. 2020 Dec 19;S1569-1993(20)30943-7. doi: 10.1016/j.jcf.2020.12.011.
Keywords CFTR modulators, Fertility
December 2020
Title: Vitamin D supplementation in patients with cystic fibrosis: A systematic review and meta-analysis
Authors Márk Félix Juhász, Orsolya Varannai, Dávid Németh, Zsolt Szakács, Szabolcs Kiss, Vera Dóra Izsák, Ágnes Rita Martonosi, Péter Hegyi, Andrea Párniczky
References J Cyst Fibros. 2020 Dec 18;S1569-1993(20)30940-1. doi: 10.1016/j.jcf.2020.12.008.
Keywords Meta-analysis, Nutrition, Systematic review, Vitamin D
Title: The association between the function of the cellular salt channel cystic fibrosis transmembrane conductance regulator and lung function in people with cystic fibrosis
Authors Nadine Bernasconi, Elisabeth Kieninger, Michelle Shaw, Johanna Kurz, Alexander Moeller, Felix Ratjen, Isabelle Rochat, Sanja Stanojevic, Florian Singer
References J Cyst Fibros. 2020 Dec 18;S1569-1993(20)30941-3. doi: 10.1016/j.jcf.2020.12.009.
Keywords Child, Pulmonary function, treatment
December 2020
Title: Association of Inhaled Antibiotics in Addition to Standard Intravenous Therapy and Outcomes of Pediatric Inpatient Pulmonary Exacerbations
Authors Jonathan D Cogen Anna V Faino, Frankline Onchiri, Lucas R Hoffman, Matthew P Kronman, Maria Nelson, David P Nichols, Margaret Rosenfeld, Donald R VanDevanter, Ronald L Gibson
References Ann Am Thorac Soc. 2020 Dec;17(12):1590-1598. doi: 10.1513/AnnalsATS.202002-179OC.
Keywords Antibiotics, Epidemiology, Pulmonary exacerbations
Theme Care of patients with CF, Lung Disease and Infection
December 2020
Title: Assessing the effect of adding chelating agent (Tris-CaEDTA) to nebulised tobramycin for improving bacterial killing and lung function in cystic fibrosis patients with Pseudomonas aeruginosa lung infection.
Authors Ramaa Puvvadi, Helga Mikkelsen, Lucy McCahon, Samantha Grogan, William Ditcham, David W Reid, Iain Lamont, Stephen M Stick, Barry Clements
References J Cyst Fibros. 2020 Dec 16;S1569-1993(20)30936-X. doi: 10.1016/j.jcf.2020.12.004.
Keywords EDTA, Pseudomonas aeruginosa, Tobramycin
Title: Ototoxicity in Cystic Fibrosis Patients Receiving Intravenous Tobramycin for Acute Pulmonary Exacerbation
Authors Emily Harruff, Jonathan Kil, Maria Gabriela Tupayachi Ortiz, Daniel Dorgan, Raksha Jain, Elizabeth A Poth, Robert C Fifer, Yun Jin M Kim, Angela G Shoup, Patrick A Flume
References J Cyst Fibros. 2020 Dec 16;S1569-1993(20)30930-9. doi: 10.1016/j.jcf.2020.11.020.
Keywords Aminoglycoside, Hearing loss, Ototoxicity, Tinnitus, Tobramycin
December 2020
Title: The impact of SARS-CoV-2 on the cystic fibrosis foundation therapeutics development network
Authors Kelsie Pearson, Nicole Mayer-Hamblett, Christopher H Goss, George Z Retsch-Bogart, Jill M VanDalfsen, Patricia Burks, Daniel Rosenbluth, John Paul Clancy, Amy Hoffman, David P Nichols
References J Cyst Fibros. 2020 Dec 15;S1569-1993(20)30939-5. doi: 10.1016/j.jcf.2020.12.007.
Keywords Clinical research, Coronavirus, SARS-CoV-2
Title: A phase 3, randomized, double-blind, parallel-group study to evaluate tezacaftor/ivacaftor in people with cystic fibrosis heterozygous
Authors Edward F McKone, Emily A DiMango, Sivagurunathan Sutharsan, Tara Lynn Barto, Daniel Campbell, Neil Ahluwalia, Mark Higgins, Caroline A Owen, Elizabeth Tullis
References J Cyst Fibros. 2020 Dec 15;S1569-1993(20)30906-1. doi: 10.1016/j.jcf.2020.11.003.
Keywords CFTR gating mutation, Clinical trial, F508del-CFTR mutation, Ivacaftor, Tezacaftor
December 2020
Title: Impact of biofilm formation and azoles' susceptibility in Scedosporium/Lomentospora species using an in vitro model that mimics the cystic fibrosis patients' airway environment
Authors Thaís P Mello, Michaela Lackner, Marta H Branquinha, André L S Santos
References J Cyst Fibros. 2020 Dec 14;S1569-1993(20)30933-4. doi: 10.1016/j.jcf.2020.12.001.
Keywords Antifungal susceptibility, Azoles, Biofilm, Mucoviscidosis, Scedosporium/Lomentospora
December 2020
Title: Environmental risks of Pseudomonas aeruginosa-What to advise patients and parents
References J Cyst Fibros. 2020 Dec 12;S1569-1993(20)30937-1. doi: 10.1016/j.jcf.2020.12.005. Online ahead of print.
Keywords Environment, Infection, Pseudomonas, Soil, Water
December 2020
Title: Amphotericin B induces epithelial voltage responses in people with cystic fibrosis
Authors Rajeev S. Chorghade, Bo Ram Kim, Janice L. Launspach, Philip H. Karp, Michael J. Welsh, Martin D. Burke
References J Cyst Fibros. 2020 Dec 8;S1569-1993(20)30928-0. doi: 10.1016/j.jcf.2020.11.018.
December 2020
Title: Organoids for personalized treatment of Cystic Fibrosis: Professional perspectives on the ethics and governance of organoid biobanking
Authors Michael A Lensink, Sarah N Boers, Karin R Jongsma, Sarah E Carter, Cornelis K van der Ent, Annelien L Bredenoord
References J Cyst Fibros. 2020 Dec 7;S1569-1993(20)30921-8. doi: 10.1016/j.jcf.2020.11.015.
Keywords Biobanking, Ethics, Governance, Organoid technology, Precision medicine, Qualitative interview study
December 2020
Title: Phages as immunomodulators and their promising use as anti-inflammatory agents in a cftr loss-of-function zebrafish model
Authors Marco Cafora, Alessia Brix, Francesca Forti, Nicoletta Loberto, Massimo Aureli, Federica Briani, Anna Pistocchi
References J Cyst Fibros. 2020 Dec 6;S1569-1993(20)30927-9. doi: 10.1016/j.jcf.2020.11.017.
Keywords Inflammation; Innate immunity, Phages, Zebrafish
December 2020
Title: Sensitive structural and functional measurements and 1-year pulmonary outcomes in pediatric cystic fibrosis
Authors Matthew M Willmering, David J Roach, Elizabeth L Kramer, Laura L Walkup, Zackary I Cleveland, Jason C Woods
References J Cyst Fibros. 2020 Dec 4;S1569-1993(20)30929-2. doi: 10.1016/j.jcf.2020.11.019.
Keywords Function, MRI, Multiple breath washout, Spirometry, Structure, Xenon
December 2020
Title: MyCyFapp clinical trial sub-study on change in PERT and fat absorption
Authors Joaquim Calvo-Lerma, Mieke Boon, Carla Colombo, Barbara de Koning, Inês Asseiceira, Maria Garriga, Maria Roca, Ine Claes, Anna Bulfamante, Sylvia Walet, Luisa Pereira, Mar Ruperto, Etna Masip, Andrea Asensio-Grau, Arianna Giana, Philine Affourtit, Ana Heredia, Saioa Vicente, Ana Andrés, Kris de Boeck, Jessie Hulst and Carmen Ribes Koninckx
References J Cyst Fibros. 2020 Dec 2;S1569-1993(20)30926-7. doi: 10.1016/j.jcf.2020.11.016.
Keywords Coefficient of fat absorption, Digestion, In vitro digestion, Paediatrics, Pancreatic enzyme replacement therapy, pancreatic insufficiency
Title: CFTR plays an important role in the regulation of vascular resistance and high-fructose/salt-diet induced hypertension in mice
Authors Ya-Ping Zhang, Lingyu Linda Ye, Hong Yuan, Dayue Darrel Duan
References J Cyst Fibros. 2020 Dec 2;S1569-1993(20)30920-6. doi: 10.1016/j.jcf.2020.11.014.
Keywords Cystic fibrosis transmembrane conductance regulator, Hypertension, Vascular tone, With-no-lysine kinase
December 2020
Title: YKL-40 as a clinical biomarker in adult patients with CF: Implications of a CHI3L1 single nucleotide polymorphism in disease severity.
Authors Adèle Coriati, Guillaume F Bouvet, Chantal Massé, Thierry Ducruet, Yves Berthiaume
References J Cyst Fibros. 2020 Dec 1;S1569-1993(20)30914-0. doi: 10.1016/j.jcf.2020.11.011.
Keywords CHI3L1, Disease severity, Single nucleotide polymorphism, YKL-40
