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Home > Study of how the G1244E cystic fibrosis mutation modifies the CFTR function and response to available CFTR modulators

Study of how the G1244E cystic fibrosis mutation modifies the CFTR function and response to available CFTR modulators

Resource Type

CF Research News

Authors

Valeria Tomati, Stefano Costa, Valeria Capurro, Emanuela Pesce, Cristina Pastorino, Mariateresa Lena, Elvira Sondo, Marco Di Duca, Federico Cresta, Simona Cristadoro, Federico Zara, Luis J V Galietta, Renata Bocciardi, Carlo Castellani
Maria Cristina Lucanto, Nicoletta Pedemonte

References

J Cyst Fibros. 2022 Dec 19;S1569-1993(22)01425-4. doi: 10.1016/j.jcf.2022.12.005.

Document

PDF icon CF Research News Article [1]

Link

Scientific Abstract [2]

Theme

CFTR/Basic Science [3]

Keywords

Chloride secretion [4]
Corrector [5]
Gating; Modulators [6]
Potentiator [7]
Stabilizer [8]
Theratype [9]

Date

Monday, December 19, 2022

Featured resource article

Yes

Resource - Guideline Type

Other Guidelines [10]
Source URL:https://www.ecfs.eu/resource-article/cf-research-news/study-how-g1244e-cystic-fibrosis-mutation-modifies-cftr-function

Links
[1] https://www.ecfs.eu/sites/default/files/cf-research-article-files/JCF-D-22-00364R1_FINAL_Pedemonte_260223.pdf [2] https://pubmed.ncbi.nlm.nih.gov/36543707/ [3] https://www.ecfs.eu/research-article-themes/cftrbasic-science [4] https://www.ecfs.eu/research-article-keywords/chloride-secretion [5] https://www.ecfs.eu/research-article-keywords/corrector [6] https://www.ecfs.eu/research-article-keywords/gating-modulators [7] https://www.ecfs.eu/research-article-keywords/potentiator [8] https://www.ecfs.eu/research-article-keywords/stabilizer [9] https://www.ecfs.eu/research-article-keywords/theratype [10] https://www.ecfs.eu/resource-guideline-type/other-guidelines