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Home > CFTR activity is enhanced by the novel corrector GLPG2222, given with and without ivacaftor in two randomized trials

CFTR activity is enhanced by the novel corrector GLPG2222, given with and without ivacaftor in two randomized trials

Resource Type

CF Research News

Authors

Bell SC, Barry PJ, De Boeck K, Drevinek P, Elborn JS, Plant BJ, Minić P, Van Braeckel E, Verhulst S, Muller K, Kanters D, Bellaire S, de Kock H, Geller DE, Conrath K, Van de Steen O, van der Ent K

References

J Cyst Fibros. 2019 Sep;18(5):700-707. doi: 10.1016/j.jcf.2019.04.014.

Document

PDF icon CF Research News Article [1]

Link

Scientific Abstract [2]

Keywords

CFTR modulator [3]
F508del [4]
GLPG2222 [5]
Gating mutation [6]
Ivacaftor [7]

Date

Wednesday, September 18, 2019

Featured resource article

Yes

Resource - Guideline Type

Other Guidelines [8]
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European Cystic Fibrosis Society (ECFS)

Source URL:https://www.ecfs.eu/resource-article/cf-research-news/cftr-activity-enhanced-novel-corrector-glpg2222-given-and-without

Links
[1] https://www.ecfs.eu/sites/default/files/cf-research-article-files/JCF-D-19-00065R2_FINAL_Bell_150619.pdf [2] https://www.ncbi.nlm.nih.gov/pubmed/?term=CFTR%20ACTIVITY%20IS%20ENHANCED%20BY%20THE%20NOVEL%20CORRECTOR%20GLPG2222%2C%20GIVEN%20WITH%20AND%20WITHOUT%20IVACAFTOR%20IN%20TWO%20RANDOMIZED%20TRIALS [3] https://www.ecfs.eu/research-article-keywords/cftr-modulator [4] https://www.ecfs.eu/research-article-keywords/f508del [5] https://www.ecfs.eu/research-article-keywords/glpg2222 [6] https://www.ecfs.eu/research-article-keywords/gating-mutation [7] https://www.ecfs.eu/research-article-keywords/ivacaftor [8] https://www.ecfs.eu/resource-guideline-type/other-guidelines