Dublin Conference - Speakers Presentations
Please click on the links (where available) to view the presentations given at the Dublin 2012 conference.
Wednesday 6 June |
|
| 17:00-18:00 | ECFS Annual General Meeting |
| 18:30-20:00 | Opening Plenary [1] - Gerry McElvaney |
| ECFS Award [2] - Niels Høiby | |
Thursday 7 June |
|
| 08:30-10:00 | Symposium 1 - New Genetic Diagnostic and Prognostic Tools |
| Moderators: PF Pignatti (IT) / C. Férec (FR) | |
| Impact of New Generation Sequencing - H. Cuppens (BE) | |
| CFTR2 ‘Going Live’ – G. Cutting (US) | |
| In Silico Prediction Tools [3]– J. Muller (FR) | |
| Transcript Analysis in Diagnostics [4] – S. Gallati (CH) | |
| 08:30-10:00 | Symposium 2 - Where to next with the EU Registry? |
| Moderators: M. Macek (CZ) / H. Olesen (DK) | |
| Registry Data Improvement and Transparency [5] – L. Viviani (IT) | |
| Expanding Registry Recruitment - Reaching the Missing [6] – V. Gulmans (NL) | |
| Using Registries in Phase IV Drug Development [7] - E. McKone (IE) | |
| Benchmarking in the USA [8] – M. Schechter (US) | |
| 08:30-10:00 | Symposium 3 - Reactive Airways Disease in CF |
| Moderators: D. Murphy / K. Webb (UK) | |
| How the CF Airway Smooth Muscle Reacts in Pro-inflammatory Conditions [9] - J. Martin (CA) | |
| Pharmacological and Clinical Basis of Airway Reactivity in CF - M. Fayon (FR) | |
| Bronchodilating the Obstructed CF Airway: Which Interventions [10]? – S. Elborn (UK) | |
| Clinical Consequences of non-ABPA Atopy in CF [11] – E. Kerem (IL) | |
| 08:30-10:00 | Symposium 4 - Exercise from Testing to Lifestyle |
| Moderators: H. Hebestreit (DE) / C. Reilly (IE) | |
| What Can We Learn from Exercise Testing – B. Arets (NL) | |
| Evidence Based Exercise Intervention [12] – J. Bradley (UK) | |
| Exercise Implementation in Daily Life: A Patient Perspective – S. Clarke (UK) | |
| New Gadgets to Promote Physical Activity [13] – L. Lands (CA) | |
| 08:30-10:00 | Symposium 5 - Emotional Well-Being |
| Moderators: J. Abbott (UK) / L. Goldbeck (DE) | |
| Final TIDES: International Comparisons [14] - A Quittner (US) | |
| Pharmacological Treatments for Mood Disorders [15] - M. Moran (IE) | |
| Psychological Management of Anxiety and Depression in Clinical Practice [16] – T. Havermans (BE) | |
| 08:30-10:00 | Symposium 6 - New Insights into the Microbiology of the CF Lung |
| Moderators. A. Oliver (ES) / M.Tunney (UK) | |
| The Molecular Microbiome of The Respiratory Tract [17] – K. Bruce (UK) | |
| Long Term Evolution of Pathogens in CF – N. Cramer (DE) | |
| United Airways? [18] – H. Krogh Johansen (DK) | |
| Impacts on Diagnosis and Treatment [19] - B. Tuemmler (DE) | |
| 10:00-10:30 | Coffee Break |
| 10:30-12:00 | Symposium 7 - Hot Topics in Neonatal Screening |
| Moderators: B. Linnane (IE) / P. Farrell (US) | |
| Early Prophylaxis in Screened Neonates Pro RSV [20]: M. Schechter (US) Con RSV: K. Southern (UK) Discussion |
|
| PAP for Screening – O. Sommerburg (DE) | |
| 2012 US Update [21] – P. Farrell (US) | |
| 10:30-12:00 | Symposium 8 - Difficult Nutritional Dilemmas |
| Mod.: H. Watson (UK) / S. Wolfe (UK) | |
| How Aggressive Should We Be in the Screened Patient? [22] - A. Munck (FR) | |
| Management of the Ostomy Patient - D. Kalnins (CA) | |
| Recurrent Acute Pancreatitis [23] - M. Lowe (US) | |
| Obese CF Patient - H. Mc Cabe (UK) | |
| 10:30-12:00 | Symposium 9 - Mechanisms of Inflammation |
| Moderators: C. Taggart (UK) / M. Chanson (CH) | |
| Overview of Innate Immunity – C. Taggart (UK) | |
| Interleukin 17 Pathways in CF Lung Disease – J. Davies (UK) | |
| Estrogen and Inflammation [24] – C. Greene (IE) | |
| Connexins as anti-inflammatory targets in cystic fibrosis [25] - M. Chanson (CH) | |
| 10:30-12:00 | Symposium 10 - Grand Rounds in Pulmonary Disease |
| Expert Panel: D. Bilton (UK) / K. De Boeck (BE) / H. Heijerman (NL) / I. Sermet (FR) | |
| Extracorporeal CO2 Removal in CF - is there a role? [26] - D. Nazareth (UK) | |
| A Severe Febrile Illness in a CF Patient Following Steroid Treatment for ABPA [27]. - A. Clayton (UK) | |
| Chronic Necrotising Pulmonary Aspergillosis in an Adult CF Patient [28]. - A. Clayton (UK) | |
| Disseminated Scedosporium Apiospermum Infection in the Post-transplant Setting [29] - C. Butler (AU) | |
| Acute Breathlessness in an Older Adult with CF and Recurrent Haemoptysis [30] -W. Flight (UK) | |
| Humpty Dumpty had a great fall…. and developed Cystic Fibrosis [31]? - F. Gilchrist (UK) | |
| 10:30-12:00 | Symposium 11 - Long Term Consequences of Improved CF Care |
| Moderators: S. Bell (AU) / G. Taccetti (IT) | |
| Metabolic Complications of Ageing [32] - B. Plant (IE) | |
| Dealing with Chronic Renal Failure – M. Walshaw (UK) | |
| Drug-induced Complications [33] – D. Peckham (UK) | |
| It Is My Life – O. Tinsley (IE) | |
| 10:30-12:00 | Symposium 12 - Novel Approaches to P. aeruginosa Target Identification, Validation and Inhibition |
| Moderators: M. Camara (UK) / G. Döring (DE) | |
| Animal models for drug development [34] - L. Eberl (CH) | |
| New Targets from combined in vitro and animal screening of P. aeruginosa [35] - M. Camara (UK) | |
| POL7080, a novel antibiotic against Pseudomonas based on the Protein Epitope Mimetics Technology -K. Dembowsky (CH) | |
| P. aeruginosa Crystal Structures for Drug Optimisation – J. Naismith (UK) | |
| 12:00-15:00 | Lunch |
| 12:30-14:00 | Gilead Satellite Symposia - Programme [36]  |
| 12:30-14:00 | Pharmaxis Satellite Symposia - Programme [37]  |
| 14:00-15:00 | Guided Poster Tours and Posters for Discussion |
| 14:00-15:00 | ePoster Corner Sessions |
| 15:00-16:30 | Workshop1 - CF below the Diaphragm |
| Moderators: L. Hjelte (SE) / C. Taylor (UK) | |
| WS1.1 - Liver Disease in Cystic Fibrosis [38] – B. Bourke (IE) | |
| WS1.2 - Rate of Decline in Serum Trypsinogen as a Validation for the PIP Score [39] – K. Keenan (CA) | |
| WS1.3 - Prevalence of Cystic Fibrosis Related Diabetes Unaffected by Steadily Improving Clinical Condition. A Danish Retrospective Birth Cohort [40]. – K. Knudsen (DK) | |
| WS1.4 - The glucose metabolism in CFRD : comparing the different methods for screening CFRD [41] – C. Mainguy (FR) | |
| WS1.5 - The Use of Bedside Ultrasonography to Identify Delayed Gastric Emptying in Cystic Fibrosis [42]– D. Nazareth (UK) | |
| WS1.6 - The Need Of An Appropriate Diagnosis Of Gastroesophageal Reflux Disease In Cystic Fibrosis Patients: Impact On Clinical Management [43] – F. Alghisi (IT) | |
| WS1.7 - Gastroesophageal reflux in adult cystic fibrosis: a primary phenomenon or secondary to respiratory dysfunction? – A. Pauwels (BE) | |
| WS1.8 - Risks of PPI treatment in patients with cystic fibrosis: effect of gastric juice of patients “on” PPI on IL-8 production by CF primary bronchial epithelial cells. – A. Pauwels (BE) | |
| 15:00-16:30 | Workshop 2 - Controlling Epithelial Inflammation |
| Moderators: P. McCray (US) / JM Sallenave (FR) | |
| WS2.1 - Investigation of MiRNA Regulation of ER Stress in Cystic Fibrosis Airway Epithelium – I. Oglesby (IE) | |
| WS2.2 - Partially degraded N-terminal half delF508 CFTR molecule produces aggregation rearrangement of intermediate filaments in fully differentiated human bronchial epithelium [44] - K. Du (CA) | |
| WS2.3 - Pseudomonas aeruginosa Enhanced Gap Junctional Communication by a TLR5 and MAPK-Dependent Mechanism in Airway Epithelial Cells [45]– D. Losa (CH) | |
| WS2.4 - Cx26 regulates Klf Gene Expression and Proliferation of Human Airway Epithelial Cells Undergoing Repair – M. Chanson (CH) | |
| WS2.5 - Airway epithelial regeneration is abnormal in CF in absence of endogenous infection and inflammation [46] – D. Adam (FR) | |
| WS2.6 - Potassium Channel Currents Induced by Lipoxin Stimulate Airway Epithelial Repair [47] – P. Buchanan (IE) | |
| WS2.7 - Rapid Effect of 17?-Estradiol on Airway Surface Liquid Hydration of Normal and Cystic Fibrosis Epithelia [48]– V. Saint-Criq (IE) | |
| WS2.8 - Slc26a9-mediated Cl- secretion is enhanced in allergic airway inflammation and prevents mucus obstruction in mouse airways [49] – P. Anagnostopoulou (DE) | |
| WS2.9 - Expression and regulation of IFRD1 in neutrophils of cystic fibrosis patients [50] – A. Hector (DE) | |
| 15:00-16:30 | Workshop 3 - Changing Epidemiology and Outcomes |
| Moderators: M. Schechter (US) / D. Taylor-Robinson (UK) | |
| WS3.1 - Changing incidence of CF in Ireland? [51] – P. Mayne (IE) | |
| WS3.2 - Who is reported in the Belgian, Dutch and French CF registries? [52] – M. Thomas (BE) | |
| WS3.3 - Longitudinal Changes in Lung Function and Risk of Death in Cystic Fibrosis: Developing a Joint Model for the UK Population – D. Taylor-Robinson (UK) | |
| WS3.4 - Determinants of Lung Disease Progression in Children with CF [53]– P. Farrell (US) | |
| WS3.5 - Patients Diagnosed with CF in Adulthood; Clinical Course Following Diagnosis and Treatment at a Regional UK Centre [54] – C. Etherington (UK) | |
| WS3.6 - The CF-ABLE Score: A Novel Clinical Prediction Tool in Cystic Fibrosis – C. McCarthy (IE) | |
| WS3.7 - Survival at low lung function in cystic fibrosis: cohort study from 1995 to 2010 [55] – M. Osman (UK) | |
| WS3.8 - The effect of socioeconomic deprivation on clinical outcomes in Cystic Fibrosis [56] – I. Doull (UK) | |
| WS3.9 - How much importance should we attribute to socioeconomic status in families with patients with CF? [57] – P. Lambrecht (BE) | |
| 15:00-16:30 | Workshop 4 - Adherence 2012 |
| Moderators: K. Russo (UK) / V. Bregnballe (DK) | |
| WS4.1 - Clinical Supervision Improves Treatment Fidelity to an Adherence Intervention [58] – A. Alpern (US) | |
| WS4.2 - CF Patients’ beliefs about nebuliser treatment: implications for adherence to treatment – R. Mills (UK) | |
| WS4.3 - Barriers to adherence in cystic fibrosis: the perspectives of young patients and their parents [59] – V. Bregnballe (DK) | |
| WS4.4 - The Effect of Remote Monitoring and Third Party Intervention on Adherence with Inhaled Therapies in Patients with Cystic Fibrosis Using the I-neb Insight Online Patient Management System. [60] – D. Peckham (UK) | |
| WS4.5 - Knowledge and Skills in Managing CF: Data from the I Change Adherence and Raise Expectations (iCARE) Study [61] – A. Quittner (US) | |
| WS4.6 - The Psychometric Properties of CF-Specific Measures of Health Beliefs and Motivation to Adhere [62]– K. Riekert (US) | |
| 15:00-16:30 | Workshop 5 - Clearing Infections from Airways |
| Moderators: T. Lee (UK) / L. Dupont (BE) | |
| WS5.1 - Inhaled glutathione in cystic fibrosis – M. Griese (DE) | |
| WS5.2 - Inhaled Dry Powder Mannitol in Cystic Fibrosis (CF): Impact on Pulmonary Exacerbations (PEs) in the Phase III Studies (CF-301 & CF-302) [63] – D. Bilton (UK) | |
| WS5.3 - Wide Pharmacokinetic Variability Of Ciprofloxacin In Patients With Cystic Fibrosis (CF) – A Reason Of Treatment Failure? [64] – C. Dalboege (DK) | |
| WS5.4 - Aztreonam for Inhalation Solution (AZLI) in Cystic Fibrosis (CF) Patients with Chronic Burkholderia Species (BURK) Infection: Final Results from a Randomized, Placebo-Controlled Tria [65]l – E. Tullis (CA) | |
| WS5.5 - A randomised, open label phase 3 study to evaluate the efficacy and safety of a dry powder formulation of inhaled colistimethate sodium (Colobreathe®) versus tobramycin nebuliser solution (TNS) in cystic fibrosis subjects with chronic Pseudomonas aerugino [66] – M. Goldman (UK) | |
| WS5.6 - A Challenging Double-Blind, Placebo-Controlled Study of Tobramycin Inhalation Powder in Cystic Fibrosis: Results of the EDIT Trial [67]– M. Higgins (UK) | |
| 15:00-16:30 | Workshop 6 - New Therapies Targeting Basic Defects |
| Moderators: M. Boyle (US) / M. Ballmann (DE) | |
| Overview [68] – M. Boyle (US) | |
| WS6.2 - Anti-inflammatory pulmonal therapy of CF-patients with Amitriptyline and Placebo - a randomised, double-blind, placebo-controlled phase IIb multicenter, cohort-study – C. Adams (DE) | |
| WS6.3 - Measures of Nutritional Status in Two Phase 3 Trials of Ivacaftor in Subjects with Cystic Fibrosis Who Have the G551D-CFTR Mutation [69] – D. Borowitz (US) | |
| WS6.4 - Long-Term Safety and Efficacy of Ivacaftor in Subjects with Cystic Fibrosis Who Have the G551D-CFTR Mutation [70] – E. McKone (IE) | |
| WS6.5 - Ivacaftor in Subjects 6 to 11 Years of Age with Cystic Fibrosis and the G551D-CFTR Mutation [71]– J. Davies (UK) | |
| 16:30-17:00 | Coffee Break |
| 17:00-18:30 | Workshop 7 - Lung Clearance Index in Real Life |
| Moderators: J. Davies (UK) / M. Gappa (DE) | |
| WS7.2 - Lung Clearance Index: Comparison of Helium and Nitrogen Washout [72]. – J. Ophoff (BE) | |
| WS7.3 - Relationships between Lung Clearance Index (LCI), patient reported symptoms and Health Related Quality of Life (HRQoL) in CF [73]. – K. O'Neill (UK) | |
| WS7.4 - Does Lung Clearance Index Predict Time to Pulmonary Exacerbation? [74] – F. Vermeulen (BE) | |
| WS7.5 - Lung function and structure in CF infants diagnosed through newborn screening (NBS) [75]. – L. Thia (UK) | |
| WS7.6 - Effect of Ivacaftor on Lung Function in Subjects with CF Who Have the G551D-CFTR Mutation and Mild Lung Disease: a comparison of lung clearance index (LCI) vs. spirometry [76] – J. Davies (UK) | |
| 17:00-18:30 | Workshop 8 - Making Sense of CFTR |
| Moderators: C. Férec (FR) / C. Castellani (IT) | |
| WS8.1 - The First 1,000 CFTR Genes Sequenced in the Mayo Clinic Clinical Molecular Genetics Laboratory. [77] - W. Highsmith (US) | |
| WS8.2 - Evaluation of Next Generation Sequencing as a Diagnostic Tool for CFTR Rare Mutation Screening [78] – D. Beattie (UK) | |
| WS8.3 - Co-implication of the 5’ and 3’ regions of CFTR exon 10 in its alternative splicing: prediction to pathology [79] – R. Farhat (FR) | |
| WS8.4 - Consequences of partial duplications of the human CFTR gene on CF diagnosis: Mutations or Ectopic Variations [80] – V. Ladeveze (FR) | |
| WS8.5 - Help for the Interpretation of Unclassified Variants: Example of the UMD-CFTR-France Locus Specific Database [81] – C. Thèze (Fr) | |
| WS8.6 - Decision algorithm and scoring method for the classification of variants of unknown clinical significance in the CFTR gene [82] – C. Raynal (FR) | |
| WS8.7 - Preimplantation genetic diagnosis for Cystic Fibrosis using multiplex fluorescent PCR [83] – A. Girardet (FR) | |
| WS8.8 - The diffusion processes of the CFTR mutations in Brittany (France) [84] – N. Pellen (FR) | |
| WS8.9 - Identification of High Frequency non-CFTR Genetic Risk Factors [85] – J. LaRusch (US) | |
| WS8.10 - Comparative Quantitative Proteomics of Wild-Type and CF Primary Nasal and Bronchial Epithelial Cells [86] – F. Gisler (CH) | |
| 17:00-18:30 | Workshop 9 - Defending the Airways |
| Moderators: C. O’ Kane (UK) / E. Reeves (IE) | |
| WS9.1 - Clinical isolates of Prevotella histicola drive MMP-9 secretion by mononuclear cells [87] – M. Jackson (UK) | |
| WS9.2 - Abnormal Lipid Raft Structure as a Potential Cause for Impaired Neutrophil Activity in Cystic Fibrosis [88] – S. Cox (IE) | |
| WS9.3 - Contribution of the Th17 pathway in lung inflammatory response in F508del-CFTR mice [89] – S. Noel (BE) | |
| WS9.4 - A Th17- and Th2-skewed Cytokine Profile in the Lung of CF Patients Represents a Risk Factor for Infection with Pseudomonas Aeruginosa (PA) [90] – K. Tiringer (AT) | |
| WS9.5 - CF Epithelial Cells are a Source of Pulmonary Cathepsin S via Increased IRF-1 – S. Weldon (UK) | |
| WS9.6 - A role for TLR9 in Pseudomonas aeruginosa-induced lung inflammation – F. Ben Mohamed (FR) | |
| WS9.7 - Modulatory effects of Aspergillus colonization and ABPA on blood and sputum eosinophils and neutrophils in CF – Y. Gernez (US) | |
| WS9.8 - Toll Like Receptor 4 is not targeted to the lysosome in Cystic Fibrosis airway epithelial cells [91] – B. Schock (UK) | |
| WS9.9 - The CFTR Potentiator Ivacaftor Corrects Defective Degranulation of Secondary and Tertiary Granules by Cystic Fibrosis Neutrophils – K. Pohl (IE) | |
| 17:00-18:30 | Workshop 10 - Barebones of Physiotherapy |
| Moderators: I. Maguire (IE) / H. Parrott (UK) | |
| WS10.1 - Evaluation of musculoskeletal and postural function in cystic fibrosis using a physiotherapy screening tool [92] – B. Button (AU) | |
| WS10.2 - Impact of Osteopathic Manipulative Treatment on Pain of Adult Patients with Cystic Fibrosis – a Pilot Randomized Study [93] – D. Hubert (FR) | |
| WS10.3 - Thoracic Kyphosis and Complications in Adult and Paediatric CF Patients– multi centre data collaboration. [94] – C. Reilly (IE) | |
| WS10.4 - Length of Hospital Stay and Changed Weekend Physiotherapy Cystic Fibrosis Service [95] – F. Moran (AU) | |
| WS10.5 - Comprehensive Exercise Training During Hospitalization for an Acute CF Exacerbation: A Randomized Controlled Trial [96] – J. Lowman (US) | |
| WS10.6 - Canadian National Airway Clearance Study: Positive Expiratory Pressure Mask versus High Frequency Chest Wall Oscillation – J. Agnew (CA) | |
| 17:00-18:30 | Workshop 11 - Unravelling Virulence |
| Moderators.: M. Prentice (IE) / N. Hoiby (DK) | |
| WS11.1 - Role of short chain fatty acids produced by anaerobic bacteria in Cystic Fibrosis – M. Murray (IE) | |
| WS11.2 - Novel LTTR plays a key role in biofilm formation and pathogenicity in P. aeruginosa – R. McCarthy (IE) | |
| WS11.3 - A role of pulmonary cytosolic phospholipase A2 in mouse mortality by Pseudomonas aeruginosa infection [97] – Y. Wu (FR) | |
| WS11.4 - Host response to Pseudomonas aeruginosa adaptation during airway chronic infection – N. Lorè (IT) | |
| WS11.5 - Reversible Proline Hydroxylation in the Guanylate Cyclase SadC regulates alginate export in Pseudomonas aeruginosa – A. Schmidt (DE) | |
| WS11.6 - Environmental Burkholderia cenocepacia strains can disrupt epithelial integrity in bronchial epithelial cells in vitro and have a more profound effect on ZO-1 in CF cells [98]. – S. McClean (IE) | |
| WS11.7 - Expression of the NF-?B inhibitor A20 is altered in the Cystic Fibrosis epithelium [99] – B. Schock (UK) | |
| WS11.8 - Adaptation and survival of Burkholderia cenocepacia within the CF lung throughout the course of infection [100] – J. Tyrrell (IE) | |
| WS11.9 - Bacterial cis-2-unsaturated fatty acids found in the cystic fibrosis airway play a role in bacterial interspecies signalling during polymicrobial infection of the CF lung [101] – K. Twomey (IE) | |
| WS11.10 - Proteomic Analysis of the Chronically Infected CF Airways [102] – S. Pattison (UK) | |
| 17:00-18:30 | Workshop 12 - Emerging Dilemmas in CF Care |
| Mod: C. Shortt (IE) / K. Colpaert (BE) | |
| WS12.1 - The Prevalence of Substance Abuse in Cystic Fibrosis [103] – S. Malhotra (CA) | |
| WS12.2 - Outcomes of Patients With Cystic Fibrosis Admitted to an Intensive Care Unit – B. Markewitz (US) | |
| WS12.3 - Educational needs for transplanted Cystic Fibrosis Patients [104] – V. David (FR) | |
| WS12.4 - Surviving But Stigmatised: Making Sense of Living with Burkholderia Cepacia [105] – E. Smallman (UK) | |
| WS12.5 - Fathers with Cystic Fibrosis in Italy: Who Are They? How Are They Doing? [106] – B. Messore (IT) | |
| WS12.6 - Social Challenges Facing Patients with CF on Their Path to Adulthood [107] – S. Wanyama (BE) | |
| 19:00-20:30 |
Johns Hopkins University School of Medicine Satellite Symposium - Programme [108]
|
| Friday 8 June | |
| 07:15-08:15 | Round Tables [109] |
| 07:15-08:15 | Abbott Satellite Symposium - Programme [110]  |
| 08:30-10:00 | Symposium 13 - Allied Health Professionals and Nursing Research - The Next Step |
| Moderators: J. Bradley (UK) / S. Madge (UK) | |
| Identifying Funding Opportunities and Writing a Grant Proposal – M. Elkins (AU) | |
| How to Complete Regulatory Documents [111] – T. Lee (UK) | |
| Finding Collaborators, Working across Many Sites: Lessons from The Menopause Study [112] – A. Tsang (CA) | |
| Setting up a Multi-National Trial: Lessons from TIDES [113] – A. Quittner (US) | |
| 08:30-10:00 | Symposium 14 - Basic Ion Transport Defects in CF |
| Moderators.: B. Harvey (IE) / U. Seidler (DE) | |
| Insights into the Pathogenesis of CF Lung Disease from CF Pigs – M. Welsh (US) | |
| Regulation of ASL by Bioactive Lipids [114] – B. Harvey (IE) | |
| Modulating transepithelial ion transport to restore the hydration of CF airways [115]– O. Zegarra-Moran (IT) | |
| Mechanisms of NHERF-Dependent Regulation of Ion transport [116] - H. De Jonge (NL) | |
| 08:30-10:00 | Symposium 15 -Lipid Signaling – Bioactive Lipids |
| Moderators: H. Verkade (NL) / Å. Nilsson (SE) | |
| Ceramide in cystic fibrosis – E. Gulbins (DE) | |
| Modulators of sphingolipid metabolism reduce lung inflammation [117] – C. Dechecchi (IT) | |
| A role of PLA2 in the elimination of S. aureus from CF lung - Y. Wu (FR) | |
| New Lipidomic Approaches in CF [118]- M. Ollero (FR) | |
| 08:30-10:00 | Symposium 16 -Clinical Implications of Inflammation Remodelling |
| Moderators: D. Hartl (DE) / N. Regamey (CH) | |
| Inflammation and Remodelling in Infants [119] - F. Ratjen (CA) | |
| Neutrophils and Injury - D. Hartl (DE) | |
| Imaging Inflammation and Remodelling [120] - N. Regamey (CH) | |
| Biomarkers of Inflammation and Injury [121] - S. Sagel (US) | |
| 08:30-10:00 | Symposium 17 - Managing Complex Infections in Advanced Lung Disease |
| Moderators: T. Pressler (DK) / J. Foweraker (UK) | |
| Managing Methicillin-resistant Staphylococcus aureus [122] - Marianne Muhlebach (US) | |
| Achromobacter [123] – M. Skov (DK) | |
| Burkholderia cepacia complex and Other Resistant Gram Negatives [124] - P. Noone (US) | |
| Managing Non Tuberculous Mycobacteria – C. Haworth (UK) | |
| 08:30-10:00 | Symposium 18 - Outcome Measures for Clinical Trials |
| Moderators: H. Tiddens (NL) / N. Derichs (DE) | |
| Novel Outcomes - What Standards Must Be Met? [125] - I. Eichler (EMA) | |
| Lung Clearance Index [126] – S. Cunningham (UK) | |
| Chest Computed Tomography - H. Tiddens (NL) | |
| Diaries and Patient Reported Outcomes [127] – C. Goss (US) | |
| 10:00-10:30 | Coffee Break |
| 10:30-12:00 | Symposium 19 - Assisted Reproductive Medicine for CF Patients: Partner Testing and Preimplantation Diagnositcs |
| Moderators: A. Girardet (FR) / D. Barton (IE) | |
| Guidelines for Partner Testing – D. Barton (IE) | |
| PGD: State of The Art and Future Developments [128] - M. Derycke (BE) | |
| Polar body analysis as an alternative PID tool – S. Rechitsky (US) | |
| Guidelines for Preimplantation Diagnostics [129] – S. SenGupta (UK) | |
| 10:30-12:00 | Symposium 20 - Rescue Strategies |
| Moderators: L. Galietta (IT) / P. Harrison (IE) | |
| Overview of Proteins involved in Membrane Trafficking [130] - P. Harrison (IE) | |
| Target Identification – M. Amaral (PT) | |
| 3-Dimensional Structure of CFTR - I. Callebaut (FR) | |
| Small Molecules to Correct Defective CFTR Function - D. Thomas (CA) | |
| 10:30-12:00 | Symposium 21 - The Clinical Microbiology Laboratory and CF Care |
| Moderators: K. Schaffer (IE) / H. Krogh Johansen (DK) | |
| Optimal Sampling for CF Infection [131] - P. McNally (IE) | |
| Identification of Emerging Pathogens [132] - JM Rolain (FR) | |
| Pseudomonas aeruginosa Bacteraemia during Acute Exacerbation- G. Döring (DE) | |
| New Approaches to Antimicrobial Susceptibility Testing [133] – J. Foweraker (UK) | |
| 10:30-12:00 | Symposium 22 - E-Health |
| Moderators: G. Latchford (UK) / E. Hunstad (NO) | |
| Cell Phone Intervention to Improve Adherence in Adolescents with CF [134] - K. Marciel (US) | |
| Tele-Health Consultation in CF [135] - D. Reid (AU) | |
| ECORN-CF Evaluation of Its Impact [136] – K. De Rijcke (BE) | |
| Internet Interventions [137] - C. Knaevelsrud (DE) | |
| 10:30-12:00 | Symposium 23 - Taking Care of the CF Patient after Lung Transplantation |
| Moderators: L. Dupont (BE) / K. Redmond (IE) | |
| Which Patient Is Unsuitable for Lung Transplantation - P. Barry (IE) | |
| Drug Interactions and Pharmacokinetics [138] - C. Knoop (BE) | |
| Microbiology of the Lung Allograft [139] - A. Fisher (UK) | |
| Long-term Outcome and Complications [140]- L. Dupont (BE) | |
| 10:30-12:00 | Symposium 24 - Enhancing CFTR Functions - What's in the Pipeline? |
| Moderators: I. Fajac (FR) / J. Davies (UK) | |
| Blocking Sodium Channels – M. Mall (DE) | |
| Kick-Starting the Stop Mutations [141] – M. Wilschanski (IL) | |
| Correcting & Potentiating CFTR [142] – J.P. Clancy (US) | |
| Trial Design: How Long? What Age? What Do We Measure? - K. De Boeck (BE) | |
| 12:00-15:00 | Lunch |
| 12:30-14:00 | Novartis Satellite Symposium - Programme [143]  |
| 14:00-15:00 | Guided Poster Tours and Posters for Discussion |
| 14:00-15:00 | ePoster Corner Sessions |
| 15:00-16:30 | Workshop 13 - Keeping Bones Strong |
| Moderators: D. Shimmin (UK) / A. Morton (UK) | |
| WS13.1 - The effect of PPI usage on bone health in children with cystic fibrosis (CF) [144] – M. Roddy (IE) | |
| WS13.2 - Cystic fibrosis bone disease: is there a need for an earlier evaluation? [145] – F. Majo (IT) | |
| WS13.3 - Reduction in Prevalence of Osteoporosis and Osteopenia in Adult Patients Attending a Regional UK Centre: 2011 vs. 1999 [146] – C. Etherington (UK) | |
| WS13.4 - Vitamin D levels among CF adults compared to general adult population in Canada [147] – M. Mailhot (CA) | |
| WS13.5 - Effectiveness of a High-Dose Vitamin D Supplementation Regimen [148] – M. O'Driscoll (UK) | |
| WS13.6 - A Treatment Algorithm for Vitamin D Deficiency [149] – A. Ochota (UK) | |
| 15:00-16:30 | Workshop 14 - Early Stage Therapies |
| Moderators: M. Mall (DE) / O. Zegarra-Moran (IT) | |
| WS14.1 - Ivacaftor Potentiates Mutant CFTR Forms Associated with Residual CFTR Function [150] – F. Van Goor (US) | |
| WS14.2 - Efficient Delivery of the human CFTR gene to Pig lungs [151] – J. Hu (CA) | |
| WS14.3 - Human Amniotic Mesenchymal Stem Cells can Partially Correct the Cystic Fibrosis Phenotype Upon Coculture with F508del Airway Epithelial Cells – A. Carbone (IT) | |
| WS14.4 - Correction of Both NBD1 Energetics and Domain Interface is Required to Restore ?F508 CFTR Folding and Function [152] – W. Rabeh (UAE) | |
| WS14.5 – A Functional CFTR Assay Using Primary Cystic Fibrosis Intestinal Organoids – F. Dekkers (NL) | |
| WS14.6 - Beta-adrenergic sweat secretion rate as accurate biomarker for CFTR function – T. Gonska (CA) | |
| 15:00-16:30 | Workshop 15 - Sorting out the Salt |
| Moderators M. Hug (DE) / V.Urbach (IE) | |
| WS15.1 - Volume Increase in Alveolar Type II Cells Following Fusion Dependent Activation of P2X4 Receptors on Lamellar Bodies – Linking Secretion and Fluid Transport in the Lung? [153] – K. Thompson (DE) | |
| WS15.2 - Airway Surface Liquid layer height in Cystic Fibrosis Bronchial Epithelial cells is increased by Lipoxin A4 via an apical ATP release activating a P2Y receptor pathway [154] – G. Higgins (IE) | |
| WS15.3 - Channel Activating Proteases (CAPS): Identification of Novel Targets for Correcting Sodium Channel Dysfunction in Cystic Fibrosis [155] – J. Reihill (UK) | |
| WS15.4 - Study of the chloride channel ANO1 in cystic fibrosis context [156] – M. Ruffin (FR) | |
| WS15.5 - Transcomplementation by a truncation mutant of CFTR, ?27-264 CFTR rescues both trafficking and chloride channel function of ?F508 CFTR [157] – L. Cebotaru (US) | |
| WS15.6 - Upregulation of MicroRNA-148b in Cystic Fibrosis like Lung Disease of ?ENaC-overexpressing Mice – R. Agrawal (DE) | |
| 15:00-16:30 | Workshop 16 - Exercise to Energise |
| Moderators: L. Kent (UK) / W. Gruber (DE) | |
| WS16.1 - Energy expenditure during a session of physiotherapy in CF patients [158]. – F. Lessire (BE) | |
| WS16.2 - The reliability of maximal cardiopulmonary exercise testing for young cystic fibrosis patients [159]– C. Williams (UK) | |
| WS16.3 - The 6-Minute Walk Test in the follow-up of CF Lung Transplant Recipient [160] – C. Cazzarolli (IT) | |
| WS16.4 - The Relationship Between Lung Function and Modified Shuttle Test Performance in Adult Patients with Cystic Fibrosis – W. Doeleman (NL) | |
| WS16.5 - Airway Clearance Therapy and Exercise in Cystic Fibrosis: Patient´s Perceptions Versus Participation [161]. – F. Kennedy (IE) | |
| WS16.6 - Efficacy of an Educational Intervention of Physical Activity for Children and Adolescents with Cystic Fibrosis [162] – P. Marostica (BR) | |
| WS16.7 - Development of an Incremental Field Exercise Test for Children with Cystic Fibrosis [163]. – S. Rand (UK) | |
| WS16.8 - Habitual physical activity in adults with cystic fibrosis compared to controls [164] – B. Button (AU) | |
| WS16.9 - 12-Month Intensive Individualised Exercise Training Improves VO2Peak in a Group of Children With Low-Medium Initial Fitness Level [165] – S. Ledger (UK) | |
| WS16.10 - Correlation between different tests to assess exercise capacity in patients with cystic fibrosis(CF) [166] – M. Donà (IT) | |
| 15:00-16:30 | Workshop 17 - Understanding the Inflamed Airway |
| Moderators: C. Taggart (UK) / D. Hartl (DE) | |
| WS17.1 - Modulation of inflammatory mediators associated with cystic fibrosis by alpha-1 antitrypsin. – D. Bergin (IE) | |
| WS17.2 - Anti-inflammatory therapy in a mouse model of P. aeruginosa lung infection leads to bacteraemia – G. Döring (DE) | |
| WS17.3 - Alteration of human macrophages functions in cystic fibrosis [167] – K. Simonin-Le Jeune (FR) | |
| WS17.4 - Anti-pseudomonas IgY antibodies opsonize Pseudomonas aeruginosa, augmenting the phagocytosis activity of polymorph nuclear neutrophils [168]. – K. Thomsen (DK) | |
| WS17.5 - Increased apoptosis and lack of invariant NKT cells in patients with cystic fibrosis leads to circulating antinuclear antibodies – G. Döring (DE) | |
| WS17.6 - Cystic Fibrosis Airway Epithelial Cells Interact With Dendritic Cells To Produce Immune Tolerance – M. Brodlie (UK) | |
| WS17.7 - Itraconazole up-regulates the Vitamin D receptor and reduces T-helper 2 responses in individuals with cystic fibrosis colonized with Aspergillus fumigatus. – C. Coughlan (IE) | |
| WS17.8 - Inhibition of leukotriene B4 signaling by alpha-1 antitrypsin: support for the use of aerosolized alpha-1 antitrypsin therapy in cystic fibrosis [169]. – C. O' Dwyer (IE) | |
| WS17.9 - The B Lymphocyte Differentiation Factor, BAFF, is Expressed in the Lung of Cystic Fibrosis Patients and in a Mouse Model of Pseudomonas Aeruginosa Infection [170] – G. Saint (UK) | |
| WS17.10 - Sputum Biomarkers and The Prediction of Clinical Outcomes in Patients with Cystic Fibrosis [171]– T. Liou (US) | |
| 15:00-16:30 | Workshop 18 - Old Bugs, New Challenges |
| Moderators: M. Tunney (UK) / C. Gunaratnam (IE) | |
| WS18.1 - Failure of Eradication Therapy of Pseudomonas aeruginosa in Cystic Fibrosis: watch the nose [172] – M. Berkhout (NL) | |
| WS18.2 - Persistent elevation of antibodies against Pseudomonas aeruginosa following successful eradication? – M. Griese (DE) | |
| WS18.3 - A Twenty-Five Year Outbreak of Pseudomonas aeruginosa: Identification of the Prairie Epidemic Strain (PES) [173] – B. Glezerson (CA) | |
| WS18.4 - Heterogeneity of shared Pseudomonas aeruginosa (Pa) strains between Australian states and centres in cystic fibrosis (CF) [174]. – T. Kidd (AU) | |
| WS18.5 - MRSA in Cystic Fibrosis: potential for transmission within CF centres? [175] – D. Gilpin (UK) | |
| WS18.6 - Outbreak of Burkholderia contaminans infection in children with cystic fibrosis: short term lung function and nutritional outcome [176] – F. Renteria (AR) | |
| 16:30-17:00 | Coffee Break |
| 17:00-18:30 | Workshop 19 - Improving what we do |
| Moderators: T. Havermans (BE) / G. Leen (IE) | |
| WS19.1 - Using Microsystems Methods to Improve Nutritional Outcomes in an Adult CF Center: A Quality Improvement (QI) Initiative [177] – M. Ferrin (US) | |
| WS19.2 - Development and Application of Quality Improvement Questionnaire in Adults with Cystic Fibrosis [178]. – B. Grogan (IE) | |
| WS19.3 - Transforming clinics to support adherence: an excercise in continuous quality improvement [179] – Y. Locke (UK) | |
| WS19.4 - CF Quality Improvement Program: a Pilot Phase to experiment the US QIP Approach in France [180] – G. Rault (FR) | |
| WS19.5 - Health Status in Individuals with Cystic Fibrosis Over the Period of Transition to Adult Services [181]– A. Thorpe (UK) | |
| WS19.6 - The Frequent Flyer Programme: Results Of A 12-Month Quality Improvement Initiative Focused On Intensive Outpatient Physiotherapy And Dietetic Support [182] – S. Ledger (UK) | |
| 17:00-18:30 | Workshop 20 - Diversity and Richness: the CF Microbiome |
| Moderators: P.Murphy (IE) / K. Bruce (UK) | |
| WS20.1 - Target minority bacterial population in Cystic Fibrosis lung microbiota [183] – JM. Rolain (FR) | |
| WS20.2 - A Novel gyrB Sequence Cluster Approach for the Identification of Multiple CF Pathogens [184] – D. Kenna (UK) | |
| WS20.3 - Use of Matrix-Assisted Laser Desorption Ionisation-Time of Flight (MALDI-TOF) Mass Spectrometry for Identification of Non-Fermentative Gram Negative Bacteria in Cystic Fibrosis and Non-CF Bronchiectasis [185] – A. Lake (UK) | |
| WS20.4 - Real-time PCR (RT-PCR) provides a “window of opportunity”: optimal screening of patients with cystic fibrosis (CF) through an earlier detection of Pseudomonas aeruginosa (PA). – G. Héry-Arnaud (FR) | |
| WS20.5 - The Airway Microbiome in Children with Cystic Fibrosis – J. Renwick (IE) | |
| WS20.6 - Comparison of microbial composition in the lower airway of young children with and without cystic fibrosis using 16S rRNA gene pyrosequencing. - J. Legg (UK) | |
| 17:00-18:30 | Workshop 21 - Eurovision Screening |
| Mod: B. Linnane (IE) / J. Dankert-Roelse (NL) | |
| WS21.1 - Recruitment and Retention of Newborn Screened (NBS) Infants to an Observational Study with Invasive Outcome Measures [186]. – J. Chudleigh (UK) | |
| WS21.2 - Newbornscreening for Cystic Fibrosis with an IRT-PAP-Protocol [187] - J Hammermann (DE) | |
| WS21.3 - Cystic Fibrosis Newborn Screening protocols (IRT/IRT and IRT/DNA) comparison – Z. Kusova (RU) | |
| WS21.4 - Newborn screening for cystic fibrosis in Switzerland – Evaluation after one year – J. Barben (CH) | |
| WS21.5 - Newborn screening for cystic fibrosis - Polish four years’ experience with CFTR sequencing strategy [188] – K. Wertheim-Tysarowska (PL) | |
| WS21.6 - 11 Years of Newborn Screening (NBS): The experience in Tuscany, Italy [189] – T. Repetto (IT) | |
| WS21.7 - Newborn Screening for Cystic Fibrosis in Ontario, Canada: The First Three Years [190] – S. Zelenietz (CA) | |
| WS21.8 - Assessment of the UK CF Newborn Screening (NBS) Programme; a protocol that uses a high cut-off for the first IRT measurement [191]– K. Southern (UK) | |
| WS21.9 - Cascade testing in families of carrier newborns identified through CF newborn screening in western Brittany, France. – I. Duguépéroux (FR) | |
| WS21.10 - The Impact of a National Newborn Screening Programme on Sweat Testing Services [192] – J. Harrington (UK) | |
| 17:00-18:30 | Workshop 22 - Late Breaking Science |
| Moderators: D. Sheppard (UK) / M. Mall (DE) | |
| Review of the ECFS Basic Science conference 2012 – L. Galietta (IT) | |
| Results of the Phase 3 Study of Ataluren in Nonsense Mutation Cystic Fibrosis (nmCF) [193] - M. Konstan (US) | |
| WS6.1 - Efficacy of hypertonic saline in infants and young children: the ISIS study – F. Ratjen (CA) | |
| 17:00-18:30 | Workshop 23 - Issues in Clinical Care |
| Moderators: S. Bell (AU) / S. Gartner (ES) | |
| WS23.1 - Progression of lung disease within specific genotypes of patients with cystic fibrosis (CF) – which lung function parameter differentiates best? [194]– R. Kraemer (CH) | |
| WS23.2 - Chest X-ray Scores and Chest CT Scores Up To 5 Years Apart Are Highly Correlated [195] – D. Sanders (US) | |
| WS23.3 - Sputum Candida albicans is associated with radiological abnormalities in a cystic fibrosis cohort [196] – T. McEnery (IE) | |
| WS23.4 - High rhinovirus burden in lower airways of children with cystic fibrosis [197] – N. Regamey (CH) | |
| WS23.5 - Early recognition of CF related diabetes in children by the use of continuous glucose monitoring systems [198] – R. Rayner (UK) | |
| WS23.6 - Assessment of Renal Function in Cystic Fibrosis Patients by Estimated and Measured Glomerular Filtration Rate-A Cross-sectional Study [199]– K. Jain (UK) | |
| 17:00-18:30 | Workshop 24 - Challenges to the CF Airway |
| Moderators: T. Pressler (DK) / D. Hubert (FR) | |
| WS24.1 - Sinonasal Pathology in Adult Patients with Cystic Fibrosis [200] – M. Berkhout (NL) | |
| WS24.2 - Extensive Sinus Surgery and Follow-up can Eradicate Pathogenic Bacterial Sinusitis in Patients with Cystic Fibrosis (CF) [201] – K. Aanaes (DK) | |
| WS24.3 - Evaluation of the performance of sonic nebuliser to target maxillary sinuses [202]. – S. Le Guellec (FR) | |
| WS24.4 - Impact Of Air Pollution On Cystic Fibrosis: A Case-crossover Analysis – P. Goeminne (BE) | |
| WS24.5 - Unresponsive Patients Benefit from Switching Intravenous Antibiotic Treatments for Pulmonary Exacerbation [203] – D. VanDevanter (US) | |
| WS24.6 - Treatment of Pulmonary Infection with Mycobacterium Abscessus Complex in Adults with Cystic Fibrosis [204]– U. Hill (UK) | |
| 19:00-20:30 |
Forest Satellite Symposium - Programme [205]
|
| 21:00 | ECFS Party [206] |
| Saturday 9 June | |
| 09:00-10:30 | Symposium 25 - Treating Fungal Disease in CF |
| Moderators: B. Plant (IE) / S. Bell (AU) | |
| ABPA [207] – R. Moss (US) | |
| Aspergillus – G. McElvaney (IE) | |
| Scedosporium – JP Bouchara (FR) | |
| Other Fungal Pathogens [208] – E. Tullis (CA) | |
| 09:00-10:30 | Symposium 26 - Genetic Epidemiology of CF Lung Disease |
| Moderators: A. Mehta (UK) / M. Stern (DE) | |
| CFTR2 Genotype/Phenotype; Its Relevance to European Datasets – C. Castellani (IT) | |
| Modifier Genes from Bedside to Bench [209] – M. Drumm (US) | |
| Gene x Environment Interaction [210] - M. Collaco (US) | |
| Impact of Modifier Genes on Clinical Outcomes [211] – H. Corvol (FR) | |
| 09:00-10:30 | Symposium 27 - Liver Disease and CF |
| Moderators: M. Wilschanski (IL) / M. Rowland (IE) | |
| The possible role of bile acid derivatives in treatment of CF liver disease – L. Kazemi-Shirazi (AT) | |
| Biomarkers in CF Liver Disease [212] - K. Gaskin (AU) | |
| Ursodeoxycholic Acid Treatment: Helpful or Harmful? - H. Verkade (NL) | |
| Treatment of Chronic CF Liver Disease [213] - B. Bourke (IE) | |
| 09:00-10:30 | Symposium 28 - Use of Technological Adjuncts for Airway Clearance |
| Moderators: I. Maguire (IE) / M. Elkins (AU) | |
| Physiology of Mucociliary Clearance – M. Elkins (AU) | |
| Positive Pressure for airway clearance [214] – F. Moran (UK) | |
| High Frequency Chest Wall Oscillation [215] – M. McIlwaine (CA) | |
| New Inhalation Techniques – D. Geller (US) | |
| 09:00-10:30 | Symposium 29 - Practical Issues in End of Life Care |
| Moderators: V. Hall (UK) / S. Madge (UK) | |
| End of Life Care – What can we learn from other diseases [216]– D. Fitzsimons (UK) | |
| Psychological Issues – U. Smrekar (AT) | |
| Patient Autonomy in Decision Making at End of Life [217] - U. Pypops (BE) | |
| Models of Palliative Care [218] – S. Bourke (UK) | |
| 09:00-10:30 | Symposium 30 - Exacerbations in CF: Optimising Outcomes |
| Moderators: C. Gallagher (IE) / P. Flume (US) | |
| What Are CF Exacerbations ? Definition and Diagnosis [219] - C. Gallagher (IE) | |
| Pathogenesis and Immunobiology [220] – A. Bush (UK) | |
| Management of Exacerbations: What Works? [221] – D. Bilton (UK) | |
| How to Prevent Exacerbations? [222]– D. Sanders (US) | |
| 10:30-11:00 | Coffee Break |
| 11:00-12:30 | Plenary |
| Inflammation and Infection - Lessons from the CF Pig Model - P. McCray (US) | |
| Potentiating and Correcting CFTR [223] - K. De Boeck (BE) | |
| ECFS President's Address [224] - S. Elborn (UK) | |
| 12:30-13:00 | Closing Ceremony |
