Programme
Updated 22 March 2012
Programme Overview
| Wednesday 28 March 2012 | |
| 14:00-17:30 | Registration, Light Meal, Set-up of Posters |
| 17:30-18:00 | Official Opening of the meeting by the Conference Chairpersons |
| 18:00-19:00 | Opening Keynote Lecture - Seeking CFTR Stability - J. Riordan (US) |
| 19:00-20:00 | Welcome Reception |
| 20:00-21:30 | Dinner |
| Thursday 29 March 2012 | |
| 07:30-08:45 | Breakfast |
| 08:45-10:30 | Symposium 1 - Exploring CFTR Structure and Function Moderators: J.Riordan (US) / D. Sheppard (UK) |
| 08:45-09:10 | Full-length CFTR structure at 9 Angstrom resolution: New insights into function. - R. Ford (UK) |
| 09:10-09:35 | Coupling between catalytic cycle and pore gating in the CFTR channel - L. Csanady (HU) |
| 09:35-10:00 | On the structure of the regulatory domain of the CFTR - O. Moran (IT) |
| 10:00-10:15 | Abstract 1: Structure-Function Analysis of Interhelical Interfaces Comprised of the Intracellular Loops of CFTR - S. Molinski (CA) |
| 10:15-10:30 | Abstract 2: Conserved NBD-TMD interactions regulate the biosynthesis of ABC transporters - P. Thibodeau (US) |
| 10:30-11:00 | Coffee Break & Poster Viewing |
| 11:00-12:45 |
Symposium 2 - The Wild and Mutant CFTR Network |
| 11:00-11:25 | Correction of CFTR Misfolding Via Modulation of Protein Quality Control Machines - D. Cyr (US) |
| 11:25-11:50 | Intermediate filaments and CFTR/F508delCFTR: K8/K18/CFTR functional interaction - A. Edelman (FR) |
| 11:50-12:15 | ER Stress, GRASP, and Unconventional Trafficking of CFTR - M. Goo Lee (KR) |
| 12:15-12:30 | Pharmacological Rescue of Mutant CFTR Detected Using a Novel Fluorescence Platform - R. Frizzell (US) |
| 12:30-12:45 | Decoding Proteostasis in Cystic Fibrosis - W. Balch (US) |
| 12:45-14:30 | Lunch |
| 14:30-16:15 |
Symposium 3 - Potentiators and Correctors; Drugs for a Sick Channel |
| 14:30-14:55 | Drug discovery : integrating epigenomics, pharmacogenomics and diagnostics for future personalized medicines for cystic fibrosis patients- F. Becq (FR) |
| 14:55-15:20 | Differential effects of CFTR correctors and potentiators on the CF mutants F508del and A561E - D. Sheppard (UK) |
| 15:20-15:45 | Probing the interaction of small molecule modulatory compounds with full length reconstituted CFTR protein. - C. Bear (CA) |
| 15:45-15:55 | Abstract 3: Keratin 8 - NBD1 of CFTR complex: structural studies - A. Kupniewska (FR) |
| 15:55-16:05 | Abstract 4: CFTR corrector C18 targets the first membrane-spanning domain during synthesis - B. Kleizen (NL) |
| 16:05-16:15 | Abstract 45: Proteostasis modulation as a novel therapeutic approach in cystic fibrosis - N. Pedemonte (IT) |
| 16:15-16:45 | Coffee Break & Poster Viewing |
| 16:45-18:15 | Special Group Discussions |
| Special Group Discussion I - CFTR Biogenesis, Quality Control, and Drug Targets | |
| Moderators: A. Harris (US) / W. Skach (US) | |
| Special Group Discussion II - Understanding the CF Airway Milleu and Host Defence | |
| Moderators: J. Stutts (US) / G. Pier (US) | |
| 20:30-21:30 | Dinner |
| 21:30-23:30 | Flash Poster Session - Even Numbers |
| Poster Session - Posters with Even Numbers | |
| Friday 30 March 2012 | |
| 07:30-08:45 | Breakfast |
| 08:45-10:30 | Symposium 4 - Epithelial Ion Transport Mechanisms Moderators: R. Frizzell (US) / J. Stutts (US) |
| 08:45-09:10 | Analysing the contribution of ENaC and CFTR to airway surface fluid homeostasis - O. Zegarra-Moran (IT) |
| 09:10-09:35 | Bicarbonate-Dependent Chloride Transport Drives Fluid Secretion by the Human Airway Epithelial Cell Line Calu-3 - J. Hanrahan (CA) |
| 09:35-10:00 | Why mouse submucosal gland serous acinar cells secrete so poorly in response to cAMP - K. Foskett (US) |
| 10:00-10:10 | Abstract 9: HCO3- permeability of ANO1/TMEM16A - J. Jung (KR) |
| 10:10-10:20 | Abstract 13: 17β-Estradiol Acts Upon the C-terminal Domain of STIM1 to Inhibit Calcium Influx - J.T. Sheridan (US) |
| 10:20-10:30 | Abstract 19: Causative role of SLC26A9 in pathogenesis of bronchiectasis? - I. Sermet-Gaudelus (FR) |
| 10:30-11:00 | Coffee Break & Poster Viewing |
| 11:00-12:45 |
Symposium 5 - The Airway Surface Liquid Battleground |
| 11:00-11:25 | The ASL Battleground - R. Tarran (US) |
| 11:25-11:50 | Host Defense in the CF airways – how disease impairs innate immunity - P. McCray (US) |
| 11:50-12:15 | Role of the HVCN1 proton channel in acid secretion by the airway epithelium - H. Fischer (US) |
| 12:15-12:25 | Abstract 11: Rapid Effect of 17β-Estradiol on Airway Surface Liquid Hydration in Normal and Cystic Fibrosis Bronchial Epithelia.- V. Saint-Criq (IE) |
| 12:25-12:35 | Abstract 12: The ENaC Inhibitory Domain of SPLUNC1 Restores ASL Height in CF Airway Epithelia - C.A. Hobbs (US) |
| 12:35-12:45 | Abstract 17: Role of CFTR and bicarbonate in CF mucus secretion and microrheology - P. Lesimple (CA) |
| 12:45-14:00 | Lunch |
| 14:00-18:00 | Free Afternoon |
| 18:00-19:45 | Symposium 6 - Inflammation in CF: the Chicken or the Egg? Moderators: G. Döring (DE) / A. Edelman (FR) |
| 18:00-18:25 | Inflammation in CF: a walk on the lipid side - M. Ollero (FR) |
| 18:25-18:50 | TMEM16A or CFTR channel activity suppresses proinflammatory cytokines secretion of human cystic fibrosis respiratory epithelia - G. Lukacs (CA) |
| 18:50-19:15 | Evidence that Absence of Functioning CFTR Does Not Intrinsically Dysregulate Autonomous Epithelial Cell Inflammatory Responses - S. Randell (US) |
| 19:15-19:25 | Abstract 23: A role of TLR9 in Pseudomonas aeruginosa-induced lung inflammation - F. Ben Mohamed (FR) |
| 19:25-19:35 | Abstract 28: Targeting enzymes involved in the metabolism of glucosylceramide to modulate transcription of IL-8 gene in CF bronchial epithelial cells - M. Tebon (IT) |
| 19:35-19:45 | Abstract 29: Neutrophil elastase degrades CFTR in vitro and in vivo and disables CFTR channel function in a P.aeruginosa lung infection model - J-M. Sallenave (FR) |
| 20:00-21:30 | Dinner |
| 21:30-23:30 | Flash Poster Session - Odd Numbers |
| Poster Session - Posters with Odd Numbers | |
| Saturday 31 March 2012 | |
| 07:30-08:45 | Breakfast |
| 08:45-10:30 | Symposium 7 - Models of CF disease Moderators: J. Hanrahan (CA) / H. De Jonge (NL) |
| 08:45-09:10 | Use of A porcine Model of CF to Investigate Bacterial Erradication Defect - J. Zabner (US) |
| 09:10-09:35 | Early CFTR-Dependent Innate Immunity in the Ferret Lung - J. Engelhardt (US) |
| 09:35-10:00 | CF mouse models: similarities and differences with human CF - H. De Jonge (NL) |
| 10:00-10:10 | A functional CFTR assay using primary cystic fibrosis intestinal organoids - J. Beekman (NL) |
| 10:10-10:20 | Abstract 36: A Novel Approach to the Development of a Murine Model of CF Associated Chronic Pulmonary Bacterial Infection - A. Monahan (UK) |
| 10:20-10:30 | Abstract 37: KCNN4 potassium channel inactivation decrease lethality in a cystic fibrosis animal model.- C.A. Flores (CL) |
| 10:30-11:00 | Coffee Break & Poster Viewing |
| 11:00-12:00 | Keynote Lecture - Novel Immunological Aspects of Cystic Fibrosis - G. Döring (DE) |
| 12:00-13:30 | Lunch |
| 13:30-15:15 | Symposium 8 - Fighting Bacteria in CF Moderators: P. McCray (US) / H. Fischer (US) |
| 13:30-13:55 | Vaccination strategies against CF pathogens - G. Pier (US) |
| 13:55-14:20 | Current developments in anti-biofilm strategies and assessing their efficacy with an ex vivo sputum biofilm model - M. Vaneechoutte (BE) |
| 14:20-14:45 | Exposure of CFTR∆F508 airway epithelial cells to Pseudomonas aeruginosa biofilms, but not their non-CF counterparts, leads to neutrophil recruitment due to increased p38α MAPK activation - S. Rousseau (CA) |
| 14:45-15:00 | Abstract 26: Lipoxin A4 Delays the Invasion of Human Bronchial Epithelial and Human Cystic Fibrosis Bronchial Epithelial Cells by the pathogen Pseudomonas aeruginosa - G. Higgins (IE) |
| 15:00-15:15 | Abstract 21: Anti-Aspergillus Activity of Human Respiratory Epithelial Cells - M. Chignard (FR) |
| 15:15-15:30 | Break |
| 15:30-17:00 | Special Group Discussions |
| Special Group Discussion III - New Approaches for Expoloring the CFTR Interactome | |
| Moderators: M. Amaral (PT) / P. Fanen (FR) | |
| Special Group Discussion IV - Anti-Inflammatory and Antimirobial Strategies | |
| Moderators: A. Mehta (UK) / S. Rousseau (CA) | |
| 17:00-17:30 | Coffee Break and Poster Viewing |
| 17:30-19:15 | Symposium 9 - Cellular Functions: CFTR and beyond Moderators: P. Fanen (FR) / G. Lukacs (CA) |
| 17:30-17:55 | Differential fragmentation of wild type, F508del and CK2-related CFTR mutants - A. Mehta (UK) |
| 17:55-18:20 | microRNA-based silencing of Delta/Notch signaling promotes multiple cilia formation - P. Barbry (FR) |
| 18:20-18:45 | Stress Activated MAP KINASE Pathway(s) Regulates ER Quality Control Threshold - A. Luini (IT) |
| 18:45:19:00 | Abstract 50: F508del-CFTR ER retention, hypoxia and saturated fatty acid accumulation: a cross road to cystic fibrosis pathogenesis - L-A. Payet (FR) |
| 19:00-19:15 | Abstract 48: The F508del mutation in CFTR gene impacts bone formation – J. Jacquot (FR) |
| 20:30 | Dinner/Social Event |
| Sunday 1 April 2012 | |
| Departure | |
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