European Cystic Fibrosis Society

S69/A272 Ursodeoxycholate reduces cholate biosynthesis rate and pool size in Cftr -/- mice
F.A.J.A. Bodewes (1) , M. Wouthuyzen-Bakker (1) , M. Bijvelds (2) , H.R. de Jonge (2) ,H.J. Verkade (1)
(1) University Medical Center Groningen, Pediatric Gastroenterology and Hepatology, Groningen, Netherlands; (2) Erasmus Medical Center, Department of Biochemistry, Rotterdam, Netherlands

S15/A057 Generation of new lung-specific tet-dependent activator mice for tight and quantitative control of conditional gene expression in the murine lung
J. Duerr (1) , M. Gruner (1) , S.C. Schubert (1) , U. Haberkorn (2) , H. Bujard (3) , M. Mall (1) .
(1) University of Heidelberg, Department of Pediatrics III, Division of Pediatric Pulmonology and Cystic Fibrosis Center, Heidelberg, Germany; (2) University of Heidelberg, Department of Nuclear Medicine, Heidelberg, Germany; (3) University of Heidelberg, Zentrum für Molekulare Biologie, Heidelberg, Germany

S69/A270 Neuroendocrine characterization of the intestine of F508del CFTR mice
L. Hjelte (1) , M. Flodström-Tullberg (2), Å. Nilsson (3) N. Wierup (4) , F. Sundler (4)
(1) Karolinska Institutet, Karolinska Univ Hosp Huddinge, Stockholm CF Center, Stockholm, Sweden; (2) Karolinska Institutet, Center for Infectious Medicine,Dept of Medicine, HS, Stockholm, Sweden; (3)Lund Univ Hosp, Dept of Clinical Sciences, Gastroenterology and Nutrition, Lund, Sweden; (4) Lund University, Dept of Experimental Medical Science, Division of Neuroendocrine Cell Biology, Lund, Sweden

S15/A058 Route of application plays a distinct role for the outcome of a Pseudomonas aeruginosa airway infection in cystic fibrosis mouse models
A. Munder (1), F. Wőlbeling (1) , U. Baumann (2) , E. Gulbins (3) , B. Tümmler (1,2).
(1) Hannover Medical School, Pediatric Pneumology, Hannover, Germany; (2) Hannover Medical School, Department of Pediatrics and Adolescent Medicine, Hannover, Germany; (3) University of Duisburg-Essen, Department of Molecular Biology, Essen, Germany

S17/A063 Resveratrol improves chloride secretion in cystic fibrosis mice homozygous for the F508del mutation
A. Palem (1) , C. Bouckaert (1) , B. Dhooghe (1) , A. Leonard (2) , B. Lubamba (1), P. Wallemacq (1) , P. Lebecque (2) , T. Leal (1) .
(1) Universite Catholique de Louvain, Centre for Toxicology and Applied Pharmacology, Brussels, Belgium; (2) Universite Catholique de Louvain, Pediatric Pulmonology & Cystic Fibrosis Unit, Cliniques Saint Luc, Brussels, Belgium

S69/A271 Pancreatic and biliary secretion differ in cystic fibrosis and wild-type pigs
A. Uc (1), D.A. Stoltz (2), P. Ludwig (2), A. Pezzulo (2) , M. Griffin (1), Maisam Abu-El-Haija (1), Marwa Abu-El-Haija (1), D.K. Meyerholz (3), P. Taft (2), M.J. Welsh (2,4)
(1) University of Iowa, Pediatrics, Iowa City, United States; (2) University of Iowa, Internal Medicine, Iowa City, United States; (3) University of Iowa, Pathology, Iowa City, United States; (4) University of Iowa, Howard Hughes Medical Institute, Iowa City, United States