European Cystic Fibrosis Society

AN OPEN STUDY ON THE PHARMACOKINETICS AND SAFETY OF ITRACONAZOLE ORAL SOLUTION IN PATIENTS WITH CF
 ( 1,2)SP Conway, (1)C Etherington, (1)DG Peckham, (2)K Brownlee, (1)A Whitehead, (2)H Cunliffe
 (1)Adult and (2)Paediatric CF Units, St James's and Seacroft University Hospitals, Leeds, United Kingdom 
 

ANTI CYTOMEGALO VIRUS THERAPY IN THE FOLLOW UP POST BILATERAL LUNG TRANSPLANTATION IN CYSTIC FIBROSIS.
 G.Cimino, S. Bertasi, S. Cingolani, F. Scalercio, M.P.
 Intermite, S. Quattrucci Cystic Fibrosis Centre, Dept . of Pediatrics , University of Rome " La Sapienza", Italy 
 

MEASURES TAKEN TO MINIMISE DRUG WASTAGE IN AN ADULT CYSTIC FIBROSIS UNIT
 J Crawley, B Govin, C Cowperthwaite, MJ Ledson, and MJ Walshaw
 Regional Adult CF Unit, The Cardiothoracic Centre, Liverpool, UK 
 

 A PROSPECTIVE RANDOMIZED TRIAL ON THE NEPHROTOXICITY OF THRICE-DAILY VERSUS ONCE-DAILY TOBRAMYCIN IN CYSTIC FIBROSIS PATIENTS
(1) TW Schroeter, (1) P Eggert, (2) J Riethmueller, (2) M Stern, (1) A Claass (1)
(1) University Children's Hospital Kiel, (2) University Children's Hospital Tuebingen, Germany

ONCE DAILY DOSAGE OF INTRAVENOUS TOBRAMYCIN IN PATIENTS WITH CYSTIC FIBROSIS - INCREASED RISK FOR COCHLEA DAMAGE ?
K. Krüger¹·², S. Junge¹, R. Schönweiler², M. Ptok², M. Ballmann¹,
Medical School Hanover, ¹Paediatric Dept., ²Clin. of Communication Disorders (Phoniatrics and Pedaudiology), Hanover, Germany

OPTIMIZED INTRAVENOUS ANTIBIOTIC TREATMENT WITH CEFTA-ZIDIME (THRICE DAILY VS. CONTINUOUS) AND TOBRAMYCIN (THRICE VS. ONCE DAILY) IN CF PATIENTS
(1)J Riethmueller, (1)P Franke, (2)TW Schroeter, (2)A Claass, (1)A Busch, (1)R Ziebach, (1)R von Butler, (3)A App, (4)G Doering, (1)M Stern.
(1 ) University Children`s Hospital, Hoppe-Seyler-Str. 1, 72076 Tuebingen, Germany, (2)University Children`s Hospital Kiel, (3)University of Freiburg, (4) Hygiene-Institut, University of Tuebingen, (for German i.v.-antibiotic study group)
 

CONTINUOUS 24 HOUR INFUSION OF BETA-LACTAM ANTIBIOTICS USING ELASTOMERIC PUMP SYSTEM DEVICE
KJ. Griffiths , Dr I Gould, Dr JS Legge
Adult Cystic Fibrosis Unit, Aberdeen Royal Infirmary, Scotland, UK

SYSTEMATIC REVIEW OF SINGLE VERSUS COMBINATION INTRAVENOUS ANTIBIOTIC THERAPY FOR PEOPLE WITH CYSTIC FIBROSIS.
(1) Dr Heather Elphick, (1) Dr Anton Tan, (2) Prof Deborah Ashby, (1) Prof Rosalind Smyth.
(1) Institute of Child Health, Alder Hey Hospital, Liverpool, UK; (2) Wolfson Institute of Preventive Medicine, Queen Mary and Westfield College, London, UK

IMPROVING PHASE I STUDIES IN CYSTIC FIBROSIS CENTRES
MH Goldman, J Mason
Medical Dept. Pharmax Limited, Bexley, Kent, U.K.

ELECTIVE VERSUS SYMPTOMATIC INTRAVENOUS ANTIBIOTICS FOR CYSTIC FIBROSIS (COCHRANE REVIEW)
(1)L Breen, (2)NM Aswani
(1)Alder Hey Children's Hospital, Liverpool, UK. (2)Institute of Child Health, University of Sheffield, UK.

 CLINICAL EFFICACY OF CLARITHROMYCIN IN CF PATIENTS WITH CHRONIC LUNG INFECTION
. B Frederiksen, C Koch, N Høiby, T Pressler,.
The Copenhagen CF centre, Denmark

ANTIINFLAMMATORY EFFECTS OF MACROLID ANTIBIOTICS DEMONSTRATED BY BAL FLUID CYTOKINE LEVELS IN CHILDHOOD BRONCHIECTASIS
(1)Kiper N, (1)Yalçin E, (1)Göçmen A, (2)Ariyürek M, (3)Firat P, (4)Sahin A , (3)Mocan G. Hacettepe
University Faculty of Medicine, Departments of (1) Pediatrics-Chest Diseases Unit, (2) Radiology, (3) Pathology, (4) Anesthesiology and Reanimation. 06100-Ankara/TURKEY.

LONG-TERM EFFECT OF NEBULIZED TOBRAMYCIN ON THE CLINICAL STATUS OF CYSTIC FIBROSIS PATIENTS
Sanda Nousia-Arvanitakis and Maria Fotoulaki
Department of Pediatrics, Aristotle University of Thessaloniki, Greece 

EFFECT OF TOBRAMYCIN SOLUTION FOR INHALATION ON PULMONARY FUNCTION DECLINE RATES IN EXACERBATING AND STABLE CF PATIENTS
(1) S Fiel (2) DR VanDevanter (2) X Yu (1)
School of Medicine, Division of Pulmonary/Critical Care Medicine, MCP Hahnemann University, Philadelphia PA, USA and (2) Chiron Corporation, Seattle WA, USA 

IN-VITRO ASSESSMENT OF A TOBRAMYCIN SOLUTION NEBULISED BY THE PARI LC PLUS UTILISING A STANDARD INHALATION PATTERN COMPARED TO A BREATHING PROFILE OF A CYSTIC FIBROSIS (CF) PATIENT
M. Keller, J. Jauernig, D. Jahn, P. Stempfle, A. Balcke and E. Sommer
PARI Aerosol Research Institute, Steinerstr. 15C, D-81369 Munich, Germany

MICROBIOLOGICAL ASSESSMENT OF ANTIBIOTIC DELIVERY USING TWO NEBULISER SYSTEMS IN PATIENTS WITH CYSTIC FIBROSIS
(1)DA. Spencer, (1)N. Byrne, (2)J. Perry, (2)K. Gould
(1)Regional Paediatric Cystic Fibrosis Unit and (2)Microbiology Department, Newcastle upon Tyne Hospital NHS trust, Newcastle upon Tyne, UK.

INFLUENCE OF LUNG FUNCTION PARAMETERS ON SERUM CONCENTRATION AFTER INHALATION OF 300MG TOBRAMYCIN IN PATIENTS WITH CYSTIC FIBROSIS
G Huels, P Bittner-Dersch, D Schueler, H Lindemann
Ped. Pneumol., Univ. Children Hospital, Giessen, Germany

INHALED TOBRAMYCIN (TOBI®) IN THE TREATMENT OF PSEUDOMONAS AERUGINOSA AIRWAY COLONISATION COMPLICATING CHRONIC REJECTION AFTER LUNG TRANSPLANTATION: A CASE REPORT
L Lannefors, L Eriksson, L Mared
Department of Respiratory Medicine, University Hospital, Lund, Sweden

BRONCHIAL REACTIVITY TO INHALED ANTIBIOTICS IN CHILDREN WITH CYSTIC FIBROSIS
I. Loukou , G. Adam , S. Doudounakis
Cystic Fibrosis Department "Aghia Sophia" Children's Hospital, Athens, GREECE

 

THE ROLE OF E TEST IN ANTIBIOTIC SYNERGY TESTING IN CYSTIC FIBROSIS
MJ Gallagher, S McCallum, MJ Ledson, CA Hart and MJ Walshaw
Regional Adult CF Unit, The Cardiothoracic Centre, Liverpool, UK

THE USE OF WHOLE SPUTUM/AGAR MIXTURE TO TEST FOR ANTIBIOTIC SUSCEPTIBILITY IN CYSTIC FIBROSIS
MJ Gallagher, S McCallum, MJ Ledson, CA Hart and MJ Walshaw
Regional Adult CF Unit, The Cardiothoracic Centre, Liverpool, UK

FACTORS INFLUENCING TOBRAMYCIN TOXICITY DURING TREATMENT FOR PSEUDOMONAS AERUGINOSA
PA Stockton, A Basu, J Crawley, MJ Ledson and MJ Walshaw
Regional CF Unit, The Cardiothoracic Centre, Liverpool UK

TWO CHILDREN WHO DEVELOPED RENAL FAILURE REQUIRING DIALYSIS ON STANDARD INTRAVENOUS TREATMENT WITH CEFTAZIDIME AND AN AMINOGLYCOSIDE.
F Hampton, F Lindsay, P Singleton, J Pagan.
Teesside Cystic Fibrosis Service. South Cleveland Hospital, Middlesbrough, UK.
 

MORPHOLOGICAL EXAMINATION OF LEFT KNEE OF CHILDREN WITH CYSTIC FIBROSIS WHO RECEIVED FLUOROQUINOLONES (CIPROFLOXACIN, PEFLOXACIN)
(1)S Semykin, (2)S Postnikov, (1)V Najimov
( 1)Russian children hospital and (2)Russian State Medical University, Moscow, Russia 

FLUORINE CONTENT IN THE BONE AND CARTILAGE OF CHILDREN TREATED WITH CIPROFLOXACIN. (IN A MODEL OF THE THIGH DISTAL PART)
SS Postnikov, AJ Kamenev, JP Viter, SJ Semykin, VP Najimov
Russian Medical State University, Moscow, Russian Federation
 

SAFETY OF FLUOROQUINOLONES IN CHILDREN
(1)SS Postnikov, (2)SJ Semykin, (2)VP Najimov
(1)Russian State Medical University and (2) Russian children hospital, Moscow, Russia

LONG TERM EFFECT OF NEPHROTOXIC IV ANTIBIOTICS ON RENAL FUNCTION IN ADULT CF PATIENTS
PA Stockton, B Govin, C Cowperthwaite, MJ Ledson, and MJ Walshaw
Regional Adult CF Unit, The Cardiothoracic Centre, Liverpool UK

28-DAY INHALATION TOXICOLOGY OF POLYMYXIN E1, THE MAJOR ACTIVE COMPONENT OF COLISTIN, IN RATS AND DOGS
(1)DR VanDevanter (2)LM Rose (1)KH Sprugel
(1) Chiron Corporation, Seattle WA, USA (2) currently at ZymoGenetics, Inc., Seattle WA USA. 

HEARING IMPAIRMENT IN CYSTIC FIBROSIS
KW Southern, EF Burrows, JJ Cottrell, LJ Heaf
Regional Paediatric CF Unit, Alder Hey Children's Hospital, University of Liverpool