Round Tables
Updated 4 May 2012
Round Tables will be held on 7 and 8 June - 07:15-08:15
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Category |
7 June 2012 |
8 June 2012 |
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CFTR/Cell Biology/ Physiology |
Consequences of Defective Chloride Transport Leader: Anil Mehta Objective: A sweat gland makes 10 nanolitres of sweat per gland per min., and you have 1-5 million of them. If you assume a 100 millimoles per litre of sweat salt. Please calculate the losses per hour per day and come to have some fun discussing such issues. CFTR in a syncitium versus a lung, pancreas etc. |
CFTR Interactome Leader: Margarida Amaral Objective: The number of CFTR-interacting proteins (CIPs) has been continuously increasing and include various functional classes, namely: (i) chaperones that direct the biogenesis of CFTR, (ii) proteins that control the traffic and cellular location of CFTR and (iii) kinases and phosphatases that regulate CFTR channel activity. The objective of this roundtable is to discuss recently identified CIPs and how novel roles are emerging for these key partners of CFTR in dynamic multiprotein complexes and how we can use this information for therapeutics. |
| Proteases and Lung Disease Leader: Clifford Taggart Objective: The objective of this roundtable is to describe and discuss the role of proteases and antiproteases in the CF lung. Discussion will also focus on the use of protease inhibitors for the treatment of CF lung disease and the possibilities and problems associated with this therapeutic approach. |
Pharmacology of the CFTR Protein Leader: Nicoletta Pedemonte Objective: The roundtable is focused on current knowledge of CFTR modulators (inhibitors, potentiators and correctors) and their mechanisms of action. |
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| Clinical Trials/New Therapies | Measuring Nutrition - What's New? Leader: Anne Munck Objective: The objective of this roundtable is to present and discuss on the recent european and american standard of procedures (SOPs) for antropometry assessment in the context of clinical trials. |
Inflammatory Markers - SOPs & Controversies Leader: Lieven Dupont Objective: |
| Lung Clearance Index - How to do it & How to Use the Results Leader: Steve Cunningham Objective: |
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| Genetics/Screening/ Diagnosis | Atypical CF and counselling Leader: Pier Franco Pignatti Objective: The objective of this roundtable is to discuss the current diagnostic, prognostic, and treatment, options, of patients with mild symptoms of CF and CFTR dysfunction. The role of rare genetic variants in the NGS era will be considered. |
Modifier Genes and Prognosis |
| Mutation Prediction Tools and Genetic Reporting Leader: Carlo Castellani Objective: discussing tools used by CFTR2 to consider a mutation CF-causing; What should be included in molecular genetics labs' reports. |
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| GI/Nutrition/Metabolic Complications/Liver Disease in CF |
Advances in Liver Disease in CF Leader: Peter Lewindon Objective: The objective of this roundtable meeting is to discuss current issues surrounding the significance of liver disease in the CF population and the role of current investigations in the management of liver fibrosis. In particular, the role of liver biopsy and non-invasive assessments will be addressed. |
Role of Fatty Acids in Nutrition Leader: Lene Hjelte Objective: |
| How to Analyse and Treat Fat Malabsorption Leader: Frank Bodewes Objective: |
New Guidelines on Vitamin D in CF Leader: Daina Kalnins Objective: The objective of this roundtable is to present and discuss the new Vitamin D guidelines for patients with CF. |
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| Update on Nutrition in Diabetes Leader: Helen Watson Objective: The objective of this roundtable is to discuss recent developments in nutritional management of diabetes, focusing specifically on treatment of hypoglycaemic symptoms and glycaemic index of foods. |
Paediatric Nutritional Assessment Leader: Sue Wolfe Objective: The objective of this roundtable is to discuss the most appropriate methodology for the assessment of nutritional status in clinical and research settings. Analysis and interpretation of fat soluble vitamin status will also be addressed. |
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| Management of Diabetes in the Sick CF Patient Leader: Ronan Canavan Objective: Objective of this round table session is to outline current practices in managing the sick CF patient with diabetes vs. most current guidelines. |
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| Microbiology/Antibiotics | PK/PD Making Antibiotics Work for Patients Leader: Michael Parkins Objective: The objective of this session is to discuss how the delivery of antibacterials may be optimized to improve patient outcomes through a pulmonary exacerbation whilst minimizing the potential toxicities, care burden and cost.
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Hypermutable Pathogens in CF Leader: Antonio Oliver Objective:The objective of this Round Table is to discuss the current data on the prevalence and role of hypermutable (mutator) pathogens in cystic fibrosis chronic respiratory infection, including their impact on antibiotic resistance, bacterial evolution and adaptation to the lung environment, biofilm growth, and disease progression. |
| Epithelial Cell-Pathogen Interaction Leader: Sophie de Bentzmann Objective: How host cell-bacteria interaction observation in cellular or animal models are transposable to CF pathology? Limits, tracks? |
Micro Evolution of CF Pathogens Leader: Nina Cramer |
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| Sinus Infection Leader: Helle Krogh Johansen Objective: The objective of this roundtable session is to discuss the importance of the sinuses as a focus for bacterial colonisation and infection of the lungs. Evidence of sinus surgery influencing the lungs is sparse, and we will discuss the indications and medical treatment strategies to eradicate bacteria from the sinuses, as well as current evidence for local antibiotic therapy. |
New Antimicrobials in CF Leader: Alessandra Bragonzi Objective: The objective of this roundtable is to discuss the current treatment approaches for respiratory infections in CF and the challenge in the discovery of new antibacterial. In particular, we will discuss antimicrobial drug resistances and novel antibiotics in the pipeline to fight multi-resistant Pseudomonas aeruginosa. |
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| MRSA and CF Leader: Elliott C. Dasenbrook Objective: The objective of this roundtable is to discuss the current treatment approaches for MRSA. We will discuss systemic and inhaled antibiotic therapies in patients experiencing a MRSA associated pulmonary exacerbation as well as the approach when a clinically stable patient repeatedly cultures MRSA. |
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| Physiotherapy | Assessment of Physical Activity Across All Ages Leader: Objective: |
Intrapulmonary Percussive Ventilation Leader: Objective: |
| End of Life Issues Leader: Helen Parrott Objective: The objective of this roundtable is to discuss aspects of end of life care that might impact on the role of the physiotherapist. In addition we will draw upon experiences in discussing successful management strategies utilised during this stage of care in the individual with cystic fibrosis. |
Sinus Irrigation and Physiotherapy Leader: Fred Lessire |
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| Exercise Assessment in the Sick Patient Leader: Helge Hebestreit Objective: The objective of this roundtable is to discuss the approaches adequate for exercise testing in sick patients with special focus on the identification of exercise-associated risks, exercise capacity, and subsequent exercise counselling. |
Study Design in Allied Health Professional Research |
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| Nursing/Psychosocial | Improving Adherence Leader: Trudy Havermans Objective: The objective of this round table is to discuss participants’ clinical experiences with improving adherence to treatment in individual patients and/or groups. The aim is to identify barriers and psychological mechanisms underlying non-adherence and to generate ideas to help patients improve adherence. |
Adult Patients and Their Families Leader: Ellen Hunstad Objective |
| Crisis Intervention Leader: Alistair Duff Objective: |
Psychosocial Issues Around Transplantation Leader: Araxie Matossian Objective: The objective of the round table is to discuss issues that are facing the patients and the transplant team before during and after transplantation. |
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| Transitioning Well Leader: Jacqueline Rendall Objective: |
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| Pulmonology/Inflammation | Devices for Inhalation in CF Leader: Matthias Griese Objective: We will discuss technical means of improvement of nebulizer devices for cystic fibrosis lung disease. Pros and cons in classic treatment situations will be developed. |
Novel Inhaled Strategies |
| Eradication Therapy for Pseudomonas aeruginosa Leader: Tanja Pressler Objective: The objective of this roundtable is to discuss the current treatments approaches for eradication therapy for Pseudomonas aeruginosa. In particular we will discuss different strategies and results from published studies and personal experience. |
Palliative and End Stage Care in CF Leader: Stephen Bourke Objective: |
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| Epidemiology/Registry | Improvement of Data Collection for Registries Leader: Vincent Gulmans Objective: The goal of this round table is to exchange current and future strategies to improve data quality of national and international CF Registries. |
Survival Analyses Leader: Objective: |
| What do the patients expect from the Registries? Leader: Ulrike Pypops Objective: |
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| Benchmarking Using Registry Data Leader: Marguerite Honer Objective: |
How to Optimize the Use of Registry Data to Improve Care Leader: Bruce Marshall Objective: The objective of this roundtable is to share ideas on the various ways registry data can be used to improve clinical care including identifying opportunities, benchmarking, public reporting, and tracking center-level improvement activities. |
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