European Cystic Fibrosis Society

The Scientific programme includes 2 keynote lectures, 9 symposia, and 4 Special Group Discussions. Oral Presentations from submitted abstracts have been selected by the Scientific Committee for inclusion in the various sessions. 

Wednesday 7 April

13:00-17:30 - Registration, Light Meal and set-up of posters
17:30-18:00 - Official opening of the conference by the ECFS President and the Conference Chairpersons
18:00-19:00 - Opening keynote lecture:
                     CFTR in the GI Tract: Studies in CF Mice and CF Patients – H. De Jonge (NL) 
19:00-20:30 - Welcome Reception
20:30-21:30 - Dinner  

Thursday 8 April

07:30-08:45 - Breakfast

08:45-10:30 - Symposium 1 - CFTR2010 - a space (or spatial) odyssey 
Chairs:  R. Ford (UK) / D. Clarke (CA)
08:45-09:10 - Mass Spectrometry Studies of CFTR Phosphorylation - C. Bear (CA)
09:10-09:35 - What can we Learn about CFTR (dys)functions from 3D Structures – I. Callebaut (FR)
09:35-10:00 - CFTR 3D Structure: New Approaches - R. Ford (UK)
10:00-10:10 - Abstract 2: Understanding CFTR Biogenesis Trough The Deletion Of The Regulatory Extension (RE) And Regulatory Insertion (RI) – AC Da Paula (PT)
10:10-10:20 - Abstract 4: Role of the C-terminal extremity of CFTR NBD1 in the control of CFTR activity – A. Billet (FR)
10:20-10:30 - Abstract 43: Screening for F508del-CFTR Correctors Identified by Pharmacophore Modelling through Western blot and NBD1 Folding Assays – M. Palma (PT)

10:30-11:00 - Coffee Break

11:00-12:45 - Symposium 2 - WT and F508del CFTR trafficking - learning the rules of the road
Chairs: G. Lukacs (CA) / M. Gentzsch (US)
11:00-11:10 - Abstract: 8: Preferential sumoylation of ΔF508 CFTRand NBD1 leads to protein degradation – R. Frizzell (US)
11:10-11:20 - Abstract 10: F508del-CFTR increases intracellular Ca²⁺ signaling that causes enhanced calcium-dependent Cl^- conductance in cystic fibrosis – JR Martins (PT)
11:20-11:45 - Sequential domain folding in wild-type and ∆F508 CFTR - I. Braakman (NL)
11:45-12:10 - CFTR Folding in Vitro and in Vivo: Implications of Cooperative Domain Assembly – G. Lukacs (CA)
12:10-12:35 - Repair of CFTR Folding Defects Caused by Cystic Fibrosis Mutations - D. Clarke (CA)
12:35-12:45 - Abstract: 6: Mechanisms of F508del-CFTR Rescuing by Genetic Revertants, Low Temperature and Small Molecules – C. M. Farinha (PT)

12:45-14:30 - Lunch

14:30-16:15 - Symposium 3 - Ion transport networks in epithelial cells 
Chairs: K. Kunzelmann (DE) / B. Stanton (US) 
14:30-14:55 - Physiology of Anoctamins - K. Kunzelmann (DE)
14:55-15:20 - Slc26 anion transporters involvement in acid-activated duodenal HCO₃^- secretion - U. Seidler (DE)
15:20-15:45 - Interaction of ENaC and CFTR - M. Gentzsch (US)
15:45-15:55 - Abstract 15: Regulation of ENaC by the Stress Response Protein SERP1 – D. Faria (PT)
15:55-16:05 - Abstract 34 : Development Of A Multi-Cellular Co-Culture Model Of Normal And Cystic Fibrosis Human Airways In Vitro – A. Bielemeier (UK)
16:05-16:15 - Abstract 5: Spleen Tyrosine Kinase (SYK) phosphorylates CFTR NBD1 and interacts in vivo with CFTR – S. Luz (PT)

16:15-16:45 - Coffee Break

Parallel Special Group Discussions:
16:45-18:15 - Special Group Discussion I - Modulator insights into wt and F508ddel CFTR behaviour
Moderators: L. Galietta (IT) / I. Braakman (NL)
16:45-18:15 - Special Group Discussion II - CF biomarkers now and on the horizon
Moderators: C. De Boeck (BE) / J.P. Clancy (US)

20:30-21:30 - Dinner
21:30-23:30 - Evening Poster session - Posters with an Even Number

Friday 9 April

07:30-08:45  -  Breakfast

08:45-10:30 - Symposium 4 - Mucus Biogenesis and disruption in CF 
Chairs: C. W. Davis (US) / M. Gray (UK) 
08:45-09:10 - Airway Goblet Cells: Mucin Synthesis and Secretion – C. W. Davis (US)
09:10-09:35 - How does Mucin Biogenesis contribute to mucus accumulation in CF? - D. Thornton (UK)
09:35-10:00 - A new Assay for Modulation of Ion Transport and Mucus Clearance in Cells and Tissues: Video-rate Ultrahigh-Resolution 3D Optical Imaging by Spectral Domain Optical Coherence Tomography - S. Rowe (US)
10:00-10:10 - Abstract 13: Gap Junctions Contribute To Airway Surface Liquid Homeostasis in Human Airway Epithelial Cells – D. Losa (CH)
10:10-10:20 - Abstract 14: The switch of intestinal Slc26 exchangers from anion absorptive to HCO3- secretory mode is dependent on CFTR anion channel function – A. Singh (DE)
10:20-10:30 - Abstract 46: Proteomics Characterization of Nasal Epithelial Cells: Their Use for Biomarkers Discovery in CF – N. Charro (PT)

10;30-11:00 - Coffee Break 

11:00-12:50 - Symposium 5 - Inflammatory signalling in CF lung disease
Chairs: G. Cabrini (IT) / A. Mehta (UK)
11:00-11:05 - Introduction - A. Mehta (UK)
11:05-11:30 - Inflammatory signalling in CF lung disease - G. McElvaney (IE) 
11:30-11:55 - CFTR Intractome and Inflammation – A. Edelman (FR)
11:55-12:20 - Pharmacological Modulation of Chemotactic Signaling in CF Respiratory Models
– G.Cabrini (IT)
12:20-12:30 - Abstract 21: NF-κB Inflammatory Signalling is suppressed by CFTR in a number of Cell models – M. Hunter (UK)
12:30-12:40 - Abstract 24: Modulation of sphingolipids metabolism reduces the neutrophil chemotaxis in human and murine respiratory models in vitro and in vivo.- M. Dechecchi (IT)
12:40-12:50 - Abstract 22: IL-8 production by Calu-3 cells depressed for CFTR and in CF human airway epithelial cells - M. Chanson (CH)

12:45-14:00 - Lunch
14:00-18:00 - Free Afternoon

Parallel Special Group Discussions:
18:00-19:30 - Special Group Discussion III - Alternate restorative strategies for CF
Moderators: F. Van Goor (US) / M. Mall (DE)
18:00-19:30 - Special Group Discussion IV - Inflammation in CF - getting to the routes by digging out the roots  
Moderators: A. Mehta (UK) / M. Chanson (CH)

20:00-21:30 - Dinner
21:30-23:30 - Evening Poster session - Posters with an Odd Number

Saturday 10 April

07:30-08:45 -Breakfast

08:45-10:30 - Symposium 6 - Understanding CF microbial targets and the CF pulmonary microbiome
Chairs:  S. Elborn (UK) / J.P. Clancy (US)
08:45-09:10 - Tobramycin and FDA-approved iron chelators eliminate P. aeruginosa biofilms on cystic fibrosis airway epithelial cells – B. Stanton (US)
09:10-09:35 - Clonal variation of Pseudomonas aeruginosa isolates from CF Airways - B. Tümmler (DE)
09:35-10:00 - Anerobes and the sputum microbiome in CF - S. Elborn (UK)
10:00-10:10 - Abstract 29: Pseudomonas aeruginosa Infection Drives Functionally Unopposed Matrix Metalloproteinase Activity In Lung Parenchymal And Inflammatory Cells.- J. Moffett (UK)
10:10-10:20 - Abstract 28: Trappin-2, an antimicrobial peptide, induces a flagellin/TLR5-dependent modulation of alveolar macrophage & epithelial cell activity – D. Descamps (FR)
10:20-10:30 - Abstract 30: The effect of budesonide in a refined rat model of respiratory infection with Pseudomonas aeruginosa – E. Growcott (UK)

10:30-11:00 - Coffee Break

11:00-13:05 - Symposium 7 - Modelling of CFTR defects
Chairs: J. Engelhardt (US) / M. Drumm (US)
11:00-11:25 - Preclinical Evaluation of Therapeutic Effects of ENaC Blockers on Cystic Fibrosis-like Lung Disease in Mice - M. Mall (DE)
11:25-11:50 - Airway Disease in the CFTR-targeted Pig – D. Stolz (US)
11:50-12:15 - Characterization of a NEW CFTR Knockout Ferret Model – J. Engelhardt (US)
12:15-12:35 - Model Systems Based on Human Rectal Biopsies to Examine CFTR Modulators - J.P. Clancy (US)
12:35-12:45 - Abstract 36: Generation Of New Lung-Specific Tet-Dependent Activator Mice For Tight And Quantitative Control Of Conditional Gene Expression In The Murine Lung – J. Duerr (DE)
12:45-12:55 - Abstract 40: Plasma lipidomics reveals phenotype-associated differences within a cohort of F508del homozygous patients – M. Ollero (FR)
12:55-13:05 - Abstract 45: Evaluation of safety and gene expression with a single dose of PGM169/GL67A administered to the airways of individuals with cystic fibrosis: The UK CF Gene Therapy Consortium ‘Pilot Study’ – U. Griesenbach (UK) 

13:00-14:30 - Lunch

14:30-16:15 - Symposium 8 - CF genomic modifiers and worldwide genetics
Chair: C. De Boeck (BE) / B. Tümmler (DE)
14:30-14:55 -Modifier Genes in CF: Genome-Wide Association Study – M. Knowles (US)
14:55-15:20 - The mouse as a model for CF modifiers - M. Drumm (US)
15:20-15:45 - Defining the clinical and functional consequences of CFTR mutations G. Cutting (US)
15:45-15:55 - Abstract 39: Histone deacetylases (HDACs) and IFRD1 in CF airway epithelial cell models -  E. Blanchard (FR)
15:55-16:05 - Abstract 37: Wobble splicing at a NAGNAG acceptor site induces a mild cystic fibrosis phenotype – A. Hinzpeter (FR)
16:05-16:15 - Abstract 38: Abnormal CFTR mRNA processing: which mutations cause it, which are the consequences and how can it be treated – A. Ramalho (PT) 

16:15-16:45 - Coffee Break

16:45-18:30 - Symposium 9 - Now and Future modulators                  
Chairs: M.D. Amaral (PT) / F. Van Goor (US) 
16:45-17:10 - CFTR and CaCCs as pharmacological targets in Cystic Fibrosis – L. Galietta (IT)
17:10-17:35 - High-content Fluorescence Microscopy siRNA Screens to Track Function/Traffic of ENaC & CFTR – M.D. Amaral (PT)
17:35-18:00 - Identification and Validation of Novel Drug Targets to Treat Cystic Fibrosis: Modifiers of the Trafficking Defect of CFTRΔF508 – D. Fischer (NL)
18:00-18:10 - Abstract 44: SIV vector pseudotyped with SeV-F/HN envelope proteins produces long lasting expression in the murine lung, is readministrable and transfects human airway models. – U. Griesenbach (UK)
18:10-18:20 - Abstract 42: Effect of TS-04-95 on Primary Human Bronchial Epithelial Monolayers after a Repeated Dose Treatment – I. Uliyakina (PT)
18:20-18:30 - Abstract 7: Effect of small molecule correctors on different mutants of CFTR – L. Cebotaru (US)

18:30-18:45 - Break

18:45-19:45 - Closing keynote lecture
CFTR modulators - Targets and Opportunities - J.P. Clancy (US) / S. Rowe (US)

20:30 - Dinner/Social Event 

Sunday 11 April

Delegates Depart